Zanchi Davide, Meyer-Gerspach Anne Christin, Schmidt André, Suenderhauf Claudia, Depoorter Antoinette, Drewe Jürgen, Beglinger Christoph, Wölnerhanssen Bettina Karin, Borgwardt Stefan
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
Department of Research, St. Clara Hospital, Basel, Switzerland.
Front Psychiatry. 2018 Mar 12;9:71. doi: 10.3389/fpsyt.2018.00071. eCollection 2018.
The present randomized double-blinded cross-over study aims to extensively study the neural correlates underpinning cognitive functions in healthy subjects after acute glucose and fructose administration, using an integrative multimodal neuroimaging approach. Five minutes after glucose, fructose, or placebo administration through a nasogastric tube, 12 participants underwent 3 complementary neuroimaging techniques: 2 task-based functional magnetic resonance imaging (fMRI) sequences to assess working memory (N-back) and response inhibition (Go/No-Go) and one resting state fMRI sequence to address the cognition-related fronto-parietal network (FPN) and salience network (SN). During working memory processing, glucose intake decreased activation in the anterior cingulate cortex (ACC) relative to placebo, while fructose decreased activation in the ACC and sensory cortex relative to placebo and glucose. During response inhibition, glucose and fructose decreased activation in the ACC, insula and visual cortex relative to placebo. Resting state fMRI indicated increased global connectivity strength of the FPN and the SN during glucose and fructose intake. The results demonstrate that glucose and fructose lead to partially different partially overlapping changes in regional brain activities that underpin cognitive performance in different tasks.
本随机双盲交叉研究旨在采用综合多模态神经成像方法，广泛研究健康受试者在急性摄入葡萄糖和果糖后认知功能背后的神经关联。通过鼻胃管给予葡萄糖、果糖或安慰剂5分钟后，12名参与者接受了3种互补的神经成像技术：2个基于任务的功能磁共振成像（fMRI）序列，用于评估工作记忆（N-back）和反应抑制（Go/No-Go）；1个静息态fMRI序列，用于研究与认知相关的额顶叶网络（FPN）和突显网络（SN）。在工作记忆处理过程中，与安慰剂相比，摄入葡萄糖会降低前扣带回皮质（ACC）的激活，而与安慰剂和葡萄糖相比，摄入果糖会降低ACC和感觉皮质的激活。在反应抑制过程中，与安慰剂相比，葡萄糖和果糖会降低ACC、岛叶和视觉皮质的激活。静息态fMRI表明，在摄入葡萄糖和果糖期间，FPN和SN的整体连接强度增加。结果表明，葡萄糖和果糖会导致区域脑活动出现部分不同但部分重叠的变化，这些变化支撑着不同任务中的认知表现。
