登革病毒特异性抗体增强巴西寨卡病毒感染。
Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection.
作者信息
Castanha Priscila M S, Nascimento Eduardo J M, Braga Cynthia, Cordeiro Marli T, de Carvalho Otávio V, de Mendonça Leila R, Azevedo Elisa A N, França Rafael F O, Dhalia Rafael, Marques Ernesto T A
机构信息
Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
Faculty of Medical Science/ Institute of Biological Science, University of Pernambuco, Recife, Brazil.
出版信息
J Infect Dis. 2017 Mar 1;215(5):781-785. doi: 10.1093/infdis/jiw638.
Abstract
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
摘要
抗黄病毒抗体具有高度交叉反应性，可能通过抗体依赖增强（ADE）机制促进寨卡病毒（ZIKV）感染。我们证明，登革热特异性抗体可增强原发性巴西ZIKV毒株在表达FcγRII的K562细胞系中的感染。此外，我们证明，登革热免疫孕妇的血清样本可增强ZIKV感染。这些发现凸显了进行流行病学研究和动物模型研究以进一步证实ADE在与ZIKV感染相关的先天性和神经并发症发展中所起作用的必要性。
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本文引用的文献
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JAMA Pediatr. 2017 Mar 1;171(3):288-295. doi: 10.1001/jamapediatrics.2016.3982.
2
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PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005048. doi: 10.1371/journal.pntd.0005048. eCollection 2016 Oct.
3
Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study.2016 年 1 月至 5 月巴西寨卡病毒感染与小头畸形的关联：病例对照研究的初步报告。
Lancet Infect Dis. 2016 Dec;16(12):1356-1363. doi: 10.1016/S1473-3099(16)30318-8. Epub 2016 Sep 16.
4
Dengue Antibody and Zika: Friend or Foe?登革热抗体与寨卡病毒：是敌是友？
Trends Immunol. 2016 Oct;37(10):635-636. doi: 10.1016/j.it.2016.08.006. Epub 2016 Sep 3.
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