Hohenheim Research Center for Health Sciences, University of Hohenheim, 70599 Stuttgart, Germany.
Institute of Microbiology, University of Hohenheim, 70599 Stuttgart, Germany.
Viruses. 2018 Mar 29;10(4):158. doi: 10.3390/v10040158.
In Germany, phage research and application can be traced back to the beginning of the 20th century. However, with the triumphal march of antibiotics around the world, the significance of bacteriophages faded in most countries, and respective research mainly focused on fundamental questions and niche applications. After a century, we pay tribute to the overuse of antibiotics that led to multidrug resistance and calls for new strategies to combat pathogenic microbes. Against this background, bacteriophages came into the spotlight of researchers and practitioners again resulting in a fast growing "phage community". In October 2017, part of this community met at the 1st German Phage Symposium to share their knowledge and experiences. The participants discussed open questions and challenges related to phage therapy and the application of phages in general. This report summarizes the presentations given, highlights the main points of the round table discussion and concludes with an outlook for the different aspects of phage application.
在德国,噬菌体的研究和应用可以追溯到 20 世纪初。然而,随着抗生素在世界范围内的广泛应用,噬菌体在大多数国家的重要性逐渐降低,相应的研究主要集中在基础问题和利基应用上。一个世纪后,我们对过度使用抗生素导致的多重耐药性表示敬意,并呼吁采取新的策略来对抗致病微生物。在此背景下,噬菌体再次成为研究人员和实践者的焦点,形成了一个快速发展的“噬菌体社区”。2017 年 10 月,该社区的一部分成员在第一届德国噬菌体研讨会上齐聚一堂,分享他们的知识和经验。与会者讨论了与噬菌体治疗和噬菌体一般应用相关的开放性问题和挑战。本报告总结了会议上的演讲,突出了圆桌讨论的要点,并对噬菌体应用的不同方面进行了展望。