Garg Harshit, Prakash Sathya, Deb Koushik Sinha, Chadda Rakesh Kumar
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
BMJ Case Rep. 2018 Mar 28;2018:bcr-2017-220995. doi: 10.1136/bcr-2017-220995.
Mania-like states occurring due to neurological, metabolic or toxic conditions, without a primary mood disorder have been reported in scientific literature as secondary mania. A major clinical problem in such situations often stems from the difficulty to understand if the mood disturbance is indeed secondary to an organic cause or a coincidental primary mood disorder. Chemotherapy regimens have been associated with multiple psychiatric complications, including psychosis, mania and anxiety. Capecitabine is implicated to be associated with encephalopathy whose clinical presentation often mimics that of psychosis. However, presentations with mania have not been reported until with the capecitabine and oxaliplatin combination chemotherapy regimen. In this report, we describe a case of secondary mania in a patient suffering from carcinoma colon on treatment with chemotherapy regimen of capecitabine and oxaliplatin.
科学文献报道，由神经、代谢或中毒性疾病引起的、无原发性心境障碍的类躁狂状态被称为继发性躁狂。这种情况下的一个主要临床问题通常源于难以判断心境障碍是否确实继发于器质性病因还是偶然的原发性心境障碍。化疗方案与多种精神科并发症相关，包括精神病、躁狂和焦虑。卡培他滨被认为与脑病有关，其临床表现常类似精神病。然而，直到卡培他滨和奥沙利铂联合化疗方案出现之前，尚未有伴发躁狂的报道。在本报告中，我们描述了1例接受卡培他滨和奥沙利铂化疗方案治疗的结肠癌患者发生继发性躁狂的病例。
