Pelc Jagoda, Czarnecka-Operacz Magdalena, Adamski Zygmunt
Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland.
Postepy Dermatol Alergol. 2018 Feb;35(1):1-5. doi: 10.5114/ada.2018.73159. Epub 2018 Feb 20.
Atopic dermatitis is a chronic, recurrent inflammatory skin disease, which is frequently familial. The main cause of the disease seems to be a defect of the epidermal barrier resulting from a genetic predisposition concerning the epidermis, functioning of the immune system as well as environmental factors (which are not related to the immune system). Genes responsible for encoding protein S100, filaggrin, proteases and their inhibitors are the main genes related to the problem of epidermal barrier dysfunction. There is a close connection between structural and immunological processes. Increased expression of cytokine Th2 profile belongs to the latter category. The objective of the present paper is to describe the influence of aforementioned factors on epidermis structure and dysfunction which leads to clinical symptoms of atopic dermatitis.
特应性皮炎是一种慢性复发性炎症性皮肤病，常具有家族性。该病的主要病因似乎是由与表皮、免疫系统功能以及环境因素（与免疫系统无关）相关的遗传易感性导致的表皮屏障缺陷。负责编码蛋白质S100、丝聚合蛋白、蛋白酶及其抑制剂的基因是与表皮屏障功能障碍问题相关的主要基因。结构和免疫过程之间存在密切联系。细胞因子Th2谱的表达增加属于后者。本文的目的是描述上述因素对表皮结构和功能障碍的影响，而这种功能障碍会导致特应性皮炎的临床症状。
