Yasmen Nelufar, Aziz Md Abdullah, Tajmim Afsana, Akter Mst Irin, Hazra Amit Kumar, Rahman S M Mushiur
Department of Pharmacy, Jessore University of Science & Technology, Jessore 7408, Bangladesh.
Department of Pharmacy, Stamford University Bangladesh, Dhaka 1217, Bangladesh.
Evid Based Complement Alternat Med. 2018 Jan 23;2018:5617234. doi: 10.1155/2018/5617234. eCollection 2018.
In folk medicine, is used as abortifacient, laxative, febrifuge analgesic, filler of tooth cavities, and anti-HIV drug and for rheumatism and various skin infections. The present study was directed to evaluate the analgesic and anti-inflammatory activities of diethyl ether and n-hexane extracts of leaves (PSDE and PSNH). A variety of tests including formalin-induced paw licking test, acetic acid induced writhing test, and tail immersion test were used to assess the analgesic activity. In addition, xylene-induced ear edema test was used to evaluate anti-inflammatory activity of PSDE and PSNH. PSDE and PSNH at 200 and 400 mg/kg doses expressed analgesic as well as anti-inflammatory activities in mice. In formalin-induced paw licking test, acetic acid induced writhing test, and xylene-induced ear edema test, the extracts exhibited significant inhibition ( < 0.05 versus control) of pain and inflammation. Alternatively, in tail immersion test, PSDE 400 mg/kg showed significant ( < 0.05 versus control) latency at 30 min but another tested sample had no significant latency. From this study, it could be shown that leaves may contain analgesic and anti-inflammatory agents which support its use in traditional medicine.
在民间医学中，[植物名称]被用作堕胎药、泻药、退烧药、龋齿填充剂、抗艾滋病毒药物以及用于治疗风湿病和各种皮肤感染。本研究旨在评估[植物名称]叶的乙醚提取物和正己烷提取物（PSDE和PSNH）的镇痛和抗炎活性。采用多种试验，包括福尔马林诱导的舔足试验、乙酸诱导的扭体试验和尾部浸入试验来评估镇痛活性。此外，二甲苯诱导的耳肿胀试验用于评估PSDE和PSNH的抗炎活性。PSDE和PSNH在200和400mg/kg剂量时在小鼠中表现出镇痛和抗炎活性。在福尔马林诱导的舔足试验、乙酸诱导的扭体试验和二甲苯诱导的耳肿胀试验中，提取物对疼痛和炎症表现出显著抑制作用（与对照组相比，P<0.05）。另外，在尾部浸入试验中，400mg/kg的PSDE在30分钟时显示出显著的（与对照组相比，P<0.05）潜伏期，但另一个测试样品没有显著潜伏期。从这项研究可以看出，[植物名称]叶可能含有镇痛和抗炎剂，这支持了其在传统医学中的应用。
