Vitreous Retina Macula Consultants of New York, New York, New York, USA; Department of Ophthalmology, New York University School of Medicine, New York, New York, USA; CHU de Bordeaux, Service d'Ophtalmologie, Bordeaux, France.
Vitreous Retina Macula Consultants of New York, New York, New York, USA; CHU de Bordeaux, Service d'Ophtalmologie, Bordeaux, France.
Am J Ophthalmol. 2018 Jun;190:78-88. doi: 10.1016/j.ajo.2018.03.029. Epub 2018 Mar 28.
To describe a novel imaging technique, which we call "dense B-scan optical coherence tomography angiography" (DB OCTA), in which thin dense raster scans are used to produce highly resolved structural B-scans with superimposed flow signal that provide precise correlation between retinal microstructure and blood flow.
Observational case series.
Normal eyes and eyes with macular findings of interest were imaged with DB OCTA in which 150-400 OCT B-scans were acquired within a narrow area (from a single line to 1 degree) with a width of 10-30 degrees. B-scans containing 5-7 consecutive frames were processed for OCTA signal and then combined and visualized post-acquisition by application of a Gaussian filter across neighboring scans. The result was a single, smoothed, high-resolution image that contained both structural and flow information. Tracked follow-up DB OCTA was used to detect subtle changes in pathology over time.
Two hundred and thirty-seven eyes from 205 subjects aged 18-100 years (mean 72.88 ± 14.74 years) with a diverse range of macular findings were imaged with DB OCTA. Highly resolved scans showing precise localization of flow signal were readily obtained, even in patients with poor visual acuity and/or poor fixation. We present clinical examples that demonstrate the utility of DB OCTA for visualizing the associations between retinal microstructure and blood flow.
DB OCTA enables precise correlation between retinal microstructure and blood flow. The ability to obtain accurately aligned follow-up DB OCTA studies has the potential to refine the understanding and clinical management of a wide range of macular diseases.
描述一种新的成像技术，我们称之为“密集 B 扫描光相干断层血管造影术”（DB OCTA），其中使用薄而密集的光栅扫描来生成具有叠加血流信号的高分辨率结构 B 扫描，为视网膜微观结构和血流之间提供精确的相关性。
观察性病例系列。
使用 DB OCTA 对正常眼和有黄斑病变的眼进行成像，其中在一个狭窄的区域（从单一线到 1 度）内采集 150-400 个 OCT B 扫描，宽度为 10-30 度。包含 5-7 个连续帧的 B 扫描被处理用于 OCTA 信号，然后在采集后通过在相邻扫描上应用高斯滤波器进行组合和可视化。结果是一个单一的、平滑的、高分辨率的图像，包含结构和血流信息。进行跟踪式后续 DB OCTA 以检测随时间推移的病理学中的细微变化。
使用 DB OCTA 对 205 名年龄在 18-100 岁（平均 72.88 ± 14.74 岁）的 237 只眼睛进行了成像，这些眼睛的黄斑病变范围广泛。即使在视力和/或固视不良的患者中，也可以轻松获得显示精确血流信号定位的高分辨率扫描。我们提供了临床示例，展示了 DB OCTA 用于可视化视网膜微观结构和血流之间关联的效用。
DB OCTA 能够精确地将视网膜微观结构和血流联系起来。获得准确对齐的后续 DB OCTA 研究的能力有可能改进对广泛的黄斑疾病的理解和临床管理。
