Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany.
Department Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany.
Hum Brain Mapp. 2018 Jul;39(7):3018-3031. doi: 10.1002/hbm.24057. Epub 2018 Mar 30.
Brain-computer interfaces provide conscious access to neural activity by means of brain-derived feedback ("neurofeedback"). An individual's abilities to monitor and control feedback are two necessary processes for effective neurofeedback therapy, yet their underlying functional neuroanatomy is still being debated. In this study, healthy subjects received visual feedback from their amygdala response to negative pictures. Activation and functional connectivity were analyzed to disentangle the role of brain regions in different processes. Feedback monitoring was mapped to the thalamus, ventromedial prefrontal cortex (vmPFC), ventral striatum (VS), and rostral PFC. The VS responded to feedback corresponding to instructions while rPFC activity differentiated between conditions and predicted amygdala regulation. Control involved the lateral PFC, anterior cingulate, and insula. Monitoring and control activity overlapped in the VS and thalamus. Extending current neural models of neurofeedback, this study introduces monitoring and control of feedback as anatomically dissociated processes, and suggests their important role in voluntary neuromodulation.
脑机接口通过大脑衍生的反馈（“神经反馈”）提供对神经活动的意识访问。个体监测和控制反馈的能力是神经反馈疗法有效的两个必要过程，但它们的潜在功能神经解剖学仍存在争议。在这项研究中，健康受试者接收到来自其杏仁核对负面图片反应的视觉反馈。分析了激活和功能连接，以厘清不同过程中脑区的作用。反馈监测映射到丘脑、腹内侧前额叶皮层（vmPFC）、腹侧纹状体（VS）和额前皮质（rPFC）。VS 对与指令相对应的反馈作出反应，而 rPFC 活动则区分条件并预测杏仁核调节。控制涉及外侧前额叶皮层、前扣带皮层和脑岛。监测和控制活动在 VS 和丘脑重叠。这项研究扩展了当前神经反馈的神经模型，将反馈的监测和控制作为解剖分离的过程引入，并表明它们在自愿神经调节中的重要作用。
