Department of Orthopedics, Changhai hospital Affiliated to the Navy Military Medical University, Shanghai, People's Republic of China.
Department of Bone and Joint Surgery, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
J Biomed Mater Res A. 2018 Sep;106(9):2531-2539. doi: 10.1002/jbm.a.36413.
Titanium (Ti) and its alloys are widely applied as orthopedic implants for hip and knee prosthesis, fixation, and dental implants. However, Ti and its alloys are bioinert and susceptible to bacteria and biofilm formation. Strategies for improving the antibacterial properties of Ti can be divided into two approaches, namely, passive coating and active coating on the Ti surface. Passive coating on Ti mainly kills the bacteria in contact but does not kill plankton or bacteria dwell in the bone tissue around the Ti implant. Active coating mainly involves the release of antibacterial agents to kill the bacteria, but this may result in the development of bacterial resistance. Both strategies include advantages and disadvantages. This article reviews the current and potential future approaches for improving antibacterial activity on Ti. We mainly focus on current approaches for fabricating antibacterial Ti and its limitations and countermeasures, and provide direction for further studies of biofunctionalization of Ti with antibacterial properties. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A:2531-2539, 2018.
钛（Ti）及其合金被广泛用作髋关节和膝关节假体、固定装置和牙科植入物的骨科植入物。然而，Ti 及其合金是生物惰性的，容易受到细菌和生物膜的形成的影响。提高 Ti 的抗菌性能的策略可以分为两种方法，即在 Ti 表面进行被动涂层和主动涂层。Ti 的被动涂层主要杀死接触的细菌，但不能杀死浮游细菌或居住在 Ti 植入物周围骨组织中的细菌。主动涂层主要涉及释放抗菌剂来杀死细菌，但这可能导致细菌产生耐药性。这两种策略都有其优点和缺点。本文综述了提高 Ti 抗菌活性的当前和潜在的未来方法。我们主要关注目前用于制造抗菌 Ti 的方法及其局限性和对策，并为进一步研究具有抗菌性能的 Ti 的生物功能化提供了方向。© 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A：106A：2531-2539，2018。
