Connolly Catherine E
General Surgery, Royal Darwin Hospital, Darwin, 0810, Australia.
Int J Surg Case Rep. 2018;45:104-106. doi: 10.1016/j.ijscr.2018.03.032. Epub 2018 Mar 26.
Suspected thyroid malignancies are usually assumed to be primary in origin. Rarely, in 1-3% of cases, the tumour arises from a secondary source such as a melanoma or breast carcinoma. There is a growing body of research concerning metastatic spread of renal cell carcinoma to the thyroid gland.
This case report describes the presentation and diagnostic work-up of an 84yr male presenting with a goitre and hoarse voice. Histopathological examination of the excised 95 × 65 × 55 mm tissue mass revealed metastatic clear cell renal cell carcinoma.
This disease pattern has become increasingly apparent in recent literature. A literature review of 150 documented cases worldwide showed that the mean interval for this spread to occur is 9 years.
There is a need for further investigation into the underlying pathophysiology of this phenomenon and increased awareness from clinicians of its existence.
疑似甲状腺恶性肿瘤通常被认为是原发性的。在1% - 3%的病例中，肿瘤很少起源于继发性来源，如黑色素瘤或乳腺癌。关于肾细胞癌转移至甲状腺的研究越来越多。
本病例报告描述了一名84岁男性患者，以甲状腺肿和声音嘶哑就诊的临床表现及诊断检查过程。对切除的95×65×55mm组织块进行组织病理学检查，显示为转移性透明细胞肾细胞癌。
这种疾病模式在最近的文献中越来越明显。对全球150例记录病例的文献综述表明，这种转移发生的平均间隔时间为9年。
有必要进一步研究这种现象的潜在病理生理学，并提高临床医生对其存在的认识。
