2014-2016 年作为 INFORM 全球监测计划一部分收集的耐多粘菌素肠杆菌科中 mcr 型基因的流行情况。
Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program.
机构信息
International Health Management Associates, Schaumburg, Illinois, United States of America.
AstraZeneca Pharmaceuticals, Waltham, Massachusetts, United States of America.
出版信息
PLoS One. 2018 Apr 2;13(4):e0195281. doi: 10.1371/journal.pone.0195281. eCollection 2018.
Abstract
A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014-2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes. In total 3.2% (29/908) of the collection were positive for mcr, including 27 Escherichia coli, 1 Klebsiella pneumoniae and 1 Enterobacter cloacae. Twenty-four isolates possessed genes from the mcr-1 family, including the original mcr-1 (n = 22), as well as mcr-1.2 (n = 1) and mcr-1.5 (n = 1), which each differ from mcr-1 by encoding single amino acid variations. Genes from the mcr-3 family were found in isolates from Thailand, including mcr-3.1 (n = 3) and mcr-3.2 (n = 1). An E. coli isolated from a patient with a urinary tract infection in Colombia contained the recently discovered mcr-5. The full colistin-resistant collection was tested against a panel of antimicrobial agents with ceftazidime-avibactam and tigecycline exhibiting the highest activity.
摘要
一组 908 株 2014-2016 年全球临床分离的粘菌素耐药肠杆菌科细菌进行了筛选，以检测质粒携带的 mcr-1、mcr-2、mcr-3、mcr-4 和 mcr-5 基因。共发现 3.2%（29/908）的分离株 mcr 阳性，包括 27 株大肠埃希菌、1 株肺炎克雷伯菌和 1 株阴沟肠杆菌。24 株分离株携带 mcr-1 家族基因，包括原始 mcr-1（n=22），以及 mcr-1.2（n=1）和 mcr-1.5（n=1），它们在编码单个氨基酸变异方面与 mcr-1 不同。来自泰国的分离株携带 mcr-3 家族基因，包括 mcr-3.1（n=3）和 mcr-3.2（n=1）。哥伦比亚一名尿路感染患者的分离株含有最近发现的 mcr-5。整个粘菌素耐药分离株被测试了一组抗菌药物，头孢他啶-阿维巴坦和替加环素显示出最高的活性。
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