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携带质粒介导的mcr-1基因的碳青霉烯类敏感大肠埃希菌ST156引起血液感染：这是巴西黏菌素耐药性一种未被注意到的传播情况？

Plasmid-mediated mcr-1 in carbapenem-susceptible Escherichia coli ST156 causing a blood infection: an unnoticeable spread of colistin resistance in Brazil?

作者信息

Rossi Flavia, Girardello Raquel, Morais Carlos, Cury Ana Paula, Martins Layla Farage, da Silva Aline Maria, Abdala Edson, Setubal João Carlos, da Silva Duarte Alberto José

机构信息

Divisao Laboratorio Central - LIM03, Setor de Microbiologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Departamento de Bioquímica, Instituto de Química, Universidade de Sao Paulo, Sao Paulo, SP, BR.

出版信息

Clinics (Sao Paulo). 2017 Oct;72(10):642-644. doi: 10.6061/clinics/2017(10)09.

DOI:10.6061/clinics/2017(10)09
PMID:29160428
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5666441/
Abstract

OBJECTIVE

We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma.

METHODS

Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS.

RESULTS

The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of aac(6')Ib-cr and blaTEM1.

CONCLUSION

Our findings warn of the possible silent dissemination of colistin resistance by carbapenem-susceptible mcr-1 producers, as colistin susceptibility is commonly tested only among carbapenem-resistant isolates.

摘要

目的

我们描述了一种IncX4型pHC891/16mcr质粒，其携带mcr-1基因，存在于一株对黏菌素耐药但对碳青霉烯类敏感的大肠杆菌分离株（HC891/16）中，该分离株属于ST156型，在一名患有胆囊腺癌的巴西患者中引起了血液感染。

方法

使用MiSeq平台（美国Illumina公司）对菌株HC891/16进行全基因组测序。使用Mira和ABACAS进行组装。

结果

分离株仅对环丙沙星、氨苄西林和头孢西丁耐药，全基因组测序显示存在aac(6')Ib-cr和blaTEM1基因。

结论

我们的研究结果警示，碳青霉烯类敏感的mcr-1产生菌可能会导致黏菌素耐药性的隐性传播，因为通常仅在碳青霉烯类耐药分离株中检测黏菌素敏感性。

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