Department of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Post Box 17666, Al Ain, United Arab Emirates.
Department of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Post Box 17666, Al Ain, United Arab Emirates.
Peptides. 2018 Jun;104:15-23. doi: 10.1016/j.peptides.2018.03.018. Epub 2018 Mar 30.
Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mitochondrial uncoupling protein 1 (UCP 1), which facilitates the conversion of white adipose tissue (WAT) into beige adipose tissue. Irisin is distributed in various body tissues and several actions have been attributed to its presence in those tissues. It has been suggested that it plays a role in metabolic diseases, ageing, inflammation and neurogenesis. However, the circulating levels of irisin are modulated by several factors such as diet, obesity, exercise, pharmacological agents and different pathological conditions. In this review, we have discussed the mechanisms by which irisin influences the functions of different body systems and how external factors in turn affect the circulating level of irisin. In conclusion, modification of circulating irisin level may help in the management of a variety of endocrine and metabolic disorders.
鸢尾素是一种新型的肌因子和脂肪因子，由于其作用机制，最近受到了广泛关注。鸢尾素是其前体纤维连接蛋白 III 型结构域包含 5（FNDC5）蛋白经蛋白水解切割后分泌的。释放后，鸢尾素通过增加解偶联蛋白 1（UCP1）的表达发挥主要作用，这促进了白色脂肪组织（WAT）向米色脂肪组织的转化。鸢尾素分布于各种身体组织中，其存在于这些组织中具有多种作用。有人认为它在代谢性疾病、衰老、炎症和神经发生中发挥作用。然而，鸢尾素的循环水平受多种因素的调节，如饮食、肥胖、运动、药物和不同的病理状况。在这篇综述中，我们讨论了鸢尾素影响不同身体系统功能的机制，以及外部因素如何反过来影响鸢尾素的循环水平。总之，循环鸢尾素水平的改变可能有助于管理各种内分泌和代谢紊乱。
