Haghikia Arash, Landmesser Ulf
Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12203, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Postfach 65 21 33, Berlin 13316, Germany.
Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12203, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Postfach 65 21 33, Berlin 13316, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Straße 2, Berlin 10178, Germany.
Cardiol Clin. 2018 May;36(2):317-327. doi: 10.1016/j.ccl.2017.12.013.
The focus in studies of high-density lipoproteins was on their capacity to remove excess cholesterol and deliver it to the liver. Other functions and vascular effects have been described. Clinical trials and translational/genetic studies have led to a refined understanding of the role of high-density lipoprotein; it is likely not a causal cardiovascular risk factor. In healthy subjects, it limits lipid oxidation, protects endothelial cell functions/integrity, and exerts antiinflammatory/antiapoptotic effects. In patients with coronary disease or diabetes, it undergoes modifications/remodeling, resulting in dysfunctional high-density lipoprotein. We summarize recent findings about the regulation of its function and discuss the clinical implications.
高密度脂蛋白研究的重点在于其清除多余胆固醇并将其输送至肝脏的能力。其他功能及血管效应也已被描述。临床试验以及转化/遗传学研究使得对高密度脂蛋白的作用有了更精确的理解；它可能并非心血管疾病的因果风险因素。在健康受试者中，它可限制脂质氧化，保护内皮细胞功能/完整性，并发挥抗炎/抗凋亡作用。在冠心病或糖尿病患者中，它会发生修饰/重塑，导致高密度脂蛋白功能失调。我们总结了关于其功能调节的最新发现并讨论了临床意义。
