甲型肝炎病毒基因组结构与复制策略。
Hepatitis A Virus Genome Organization and Replication Strategy.
机构信息
Departments of Medicine and Microbiology & Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, North Carolina 27599.
出版信息
Cold Spring Harb Perspect Med. 2018 Dec 3;8(12):a033480. doi: 10.1101/cshperspect.a033480.
Abstract
Hepatitis A virus (HAV) is a positive-strand RNA virus classified in the genus of the family It is an ancient virus with a long evolutionary history and multiple features of its capsid structure, genome organization, and replication cycle that distinguish it from other mammalian picornaviruses. HAV proteins are produced by cap-independent translation of a single, long open reading frame under direction of an inefficient, upstream internal ribosome entry site (IRES). Genome replication occurs slowly and is noncytopathic, with transcription likely primed by a uridylated protein primer as in other picornaviruses. Newly produced quasi-enveloped virions (eHAV) are released from cells in a nonlytic fashion in a unique process mediated by interactions of capsid proteins with components of the host cell endosomal sorting complexes required for transport (ESCRT) system.
摘要
甲型肝炎病毒（HAV）是一种正链 RNA 病毒，归类于小 RNA 病毒科的 属。它是一种古老的病毒，具有独特的衣壳结构、基因组组织和复制周期特征，与其他哺乳动物小 RNA 病毒不同。HAV 蛋白通过在非效率的上游内部核糖体进入位点（IRES）的指导下，从单个长开放阅读框进行帽非依赖性翻译产生。基因组复制缓慢且非致细胞病变，转录可能由类似于其他小 RNA 病毒的尿嘧啶化蛋白引物引发。新产生的准包膜病毒（eHAV）通过衣壳蛋白与宿主细胞内体分选复合物所需的运输成分（ESCRT）系统的相互作用，以独特的方式非裂解地从细胞中释放。
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