Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio 43205.
Departments of Medicine and Microbiology & Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, North Carolina 27599.
Cold Spring Harb Perspect Med. 2019 Mar 1;9(3):a033464. doi: 10.1101/cshperspect.a033464.
Although hepatitis A virus (HAV) and hepatitis E virus (HEV) are both positive-strand RNA viruses that replicate in the cytoplasm of hepatocytes, there are important differences in the ways they induce and counteract host innate immune responses. HAV is remarkably stealthy because of its ability to evade and disrupt innate signaling pathways that lead to interferon production. In contrast, HEV does not block interferon production. Instead, it persists in the presence of an interferon response. These differences may provide insight into HEV persistence in immunocompromised patients, an emerging health problem in developed countries.
虽然甲型肝炎病毒（HAV）和戊型肝炎病毒（HEV）都是在肝细胞细胞质中复制的正链 RNA 病毒，但它们在诱导和拮抗宿主固有免疫反应方面存在重要差异。HAV 能够逃避和破坏导致干扰素产生的固有信号通路，因此具有很强的隐匿性。相比之下，HEV 并不阻止干扰素的产生。相反，它在干扰素反应存在的情况下持续存在。这些差异可能有助于解释为什么 HEV 能够在免疫功能低下的患者中持续存在，这是发达国家日益严重的健康问题。
