Department of Neuroscience Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Local Health Unit of Pescara, Italy.
J Alzheimers Dis. 2018;63(1):203-215. doi: 10.3233/JAD-171134.
Post traumatic stress disorder (PTSD) is associated with cognitive decline. The dementia type following PTSD is unclear.
To assess whether PTSD is associated with a specific dementia.
Prospective study: 46 PTSD patients (DSM-IV-TR) were followed for 6-10 years with clinical, neuropsychological, imaging evaluations for possible development of dementia.Retrospective study:849 dementia patients followed during 1999-2014 (509 Alzheimer's disease, AD; 207 dementia with Lewy bodies, DLB; 90 vascular dementia, VaD; 43 frontotemporal dementia, FTD) and 287 patients with any neurological condition (including patients with/without dementia) were evaluated for the presence of PTSD in their history.
Prospective study: 8 patients developed dementia; 1 AD, 1 DLB, 6 semantic FTD (13.0% of the PTSD population). Retrospective study: 38 patients (4.5%) had a history of PTSD; 3.5% of AD, 4.3% of DLB, 14.0% of FTD, 5.6% of VaD. The percentage was higher in FTD than in AD or DLB (χ2 = 10, p = 0.001, and χ2 = 6, p = 0.02). At difference with AD, DLB, or VaD, FTD incidence among dementia patients with PTSD history (38 patients) was higher than in the dementia population overall (16% versus 5%, χ2 = 8, p = 0.005). The impact of possible demographical/clinical confounders (age, gender, MMSE) was excluded by Poisson regression. PTSD prevalence in the comparative group without dementia matched the prevalence in the Italian general population (1.1%). PTSD prevalence in the demented comparative group matched the prevalence in our dementia retrospective cohort, 3.7%).
PTSD was associated with the development of semantic FTD.
创伤后应激障碍（PTSD）与认知能力下降有关。 PTSD 后发生的痴呆类型尚不清楚。
评估 PTSD 是否与特定类型的痴呆有关。
前瞻性研究：46 名 PTSD 患者（DSM-IV-TR）接受了 6-10 年的临床、神经心理学、影像学评估，以评估是否可能发生痴呆。回顾性研究：对 1999-2014 年期间就诊的 849 名痴呆患者（509 名阿尔茨海默病患者、AD；207 名路易体痴呆患者、DLB；90 名血管性痴呆患者、VaD；43 名额颞叶痴呆患者、FTD）和 287 名有任何神经病史的患者（包括有/无痴呆患者）进行了 PTSD 病史评估。
前瞻性研究：8 名患者发生痴呆，其中 1 例为 AD，1 例为 DLB，6 例为语义性 FTD（PTSD 人群的 13.0%）。回顾性研究：38 名患者（4.5%）有 PTSD 病史，其中 3.5%为 AD，4.3%为 DLB，14.0%为 FTD，5.6%为 VaD。与 AD 或 DLB 相比，FTD 的发生率更高（χ2 = 10，p = 0.001，和 χ2 = 6，p = 0.02）。与 AD、DLB 或 VaD 不同，PTSD 病史的痴呆患者（38 例）的 FTD 发生率高于总体痴呆人群（16%与 5%，χ2 = 8，p = 0.005）。用泊松回归排除了可能的人口统计学/临床混杂因素（年龄、性别、MMSE）的影响。无痴呆的对照组 PTSD 患病率与意大利普通人群的患病率（1.1%）相匹配。痴呆对照组的 PTSD 患病率与我们的痴呆回顾性队列相匹配，为 3.7%）。
PTSD 与语义性 FTD 的发生有关。
