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海洋藻类内生真菌 Aspergillus alabamensis EN-547 中两种新二酮吗啡啉衍生物和一种新型高共轭麦角甾烷型甾体

Two New Diketomorpholine Derivatives and a New Highly Conjugated Ergostane-Type Steroid from the Marine Algal-Derived Endophytic Fungus Aspergillus alabamensis EN-547.

机构信息

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Nanhai Road 7, Qingdao 266071, China.

University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China.

出版信息

Mar Drugs. 2018 Mar 31;16(4):114. doi: 10.3390/md16040114.

DOI:10.3390/md16040114
PMID:29614724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5923401/
Abstract

Chemical investigation of the marine algal-derived endophytic fungus EN-547 resulted in the isolation of 4---shornephine A methyl ester () and 4---shornephine A carboxylic acid (), two new secondary metabolites having a rare diketomorpholine motif, and 28-acetoxy-12,15,25-trihydroxyergosta-4,6,8(14),22-tetraen-3-one (), a new highly conjugated ergostane-type steroid, together with four known metabolites (-). Their chemical structures were elucidated by detailed analysis of their NMR spectra, ECDs, HRESIMS, optical rotation, and X-ray crystallographic data, and by comparison with literature data as well. The antimicrobial activities of compounds - were evaluated.

摘要

海洋藻类内生真菌 EN-547 的化学成分研究分离得到了 4---shornephine A 甲酯 () 和 4---shornephine A 羧酸 (), 这两个新的次生代谢产物具有罕见的二酮吗啉基序，以及 28-乙酰氧基-12,15,25-三羟基麦角甾-4,6,8(14),22-四烯-3-酮 (), 一个新的高度共轭的麦角甾烷型甾体，以及四个已知的代谢物 (-)。通过详细分析它们的 NMR 光谱、ECD、HRESIMS、旋光和 X 射线晶体学数据，并与文献数据进行比较，确定了它们的化学结构。评估了化合物 - 的抗菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/cc41e57712c8/marinedrugs-16-00114-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/c6891a772c35/marinedrugs-16-00114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/d8aeff9a46ef/marinedrugs-16-00114-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/69c958ceb9fa/marinedrugs-16-00114-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/447a2f82f627/marinedrugs-16-00114-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/f75e31cdf35c/marinedrugs-16-00114-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/cc41e57712c8/marinedrugs-16-00114-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/c6891a772c35/marinedrugs-16-00114-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/d8aeff9a46ef/marinedrugs-16-00114-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/69c958ceb9fa/marinedrugs-16-00114-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/447a2f82f627/marinedrugs-16-00114-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/f75e31cdf35c/marinedrugs-16-00114-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8a2/5923401/cc41e57712c8/marinedrugs-16-00114-g006.jpg

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