遗传和环境因素在正常个体红细胞C3b受体（ECR1）数量调节中的相对作用。
The relative roles of genetic and environmental factors in the regulation of erythrocyte C3b receptor (ECR1) numbers in normal individuals.
作者信息
Fyfe A, Holme E R, McKay I C, Zoma A, Hunter J, Lucie N P, Whaley K
机构信息
University of Glasgow Department of Pathology, Western Infirmary, UK.
出版信息
Clin Exp Immunol. 1987 Oct;70(1):231-7.
Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizygotic twins was no greater than that in monozygotic twins. These data indicate that ECR1 numerical expression is governed by environmental rather than genetic factors.
使用[125I]标记的单克隆抗体（E11）对122对双胞胎（60对同卵双胞胎，62对异卵双胞胎）的红细胞C3b受体（ECR1）进行了检测。ECR1数量范围很广，为99 - 4179个位点/细胞，围绕几何平均值837个位点/细胞呈对数正态分布。异卵双胞胎的配对内方差不大于同卵双胞胎。这些数据表明，ECR1的数值表达受环境而非遗传因素的支配。
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