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遗传和环境因素在正常个体红细胞C3b受体（ECR1）数量调节中的相对作用。

The relative roles of genetic and environmental factors in the regulation of erythrocyte C3b receptor (ECR1) numbers in normal individuals.

作者信息

Fyfe A, Holme E R, McKay I C, Zoma A, Hunter J, Lucie N P, Whaley K

机构信息

University of Glasgow Department of Pathology, Western Infirmary, UK.

出版信息

Clin Exp Immunol. 1987 Oct;70(1):231-7.

PMID:2961490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542200/
Abstract

Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizygotic twins was no greater than that in monozygotic twins. These data indicate that ECR1 numerical expression is governed by environmental rather than genetic factors.

摘要

使用[125I]标记的单克隆抗体（E11）对122对双胞胎（60对同卵双胞胎，62对异卵双胞胎）的红细胞C3b受体（ECR1）进行了检测。ECR1数量范围很广，为99 - 4179个位点/细胞，围绕几何平均值837个位点/细胞呈对数正态分布。异卵双胞胎的配对内方差不大于同卵双胞胎。这些数据表明，ECR1的数值表达受环境而非遗传因素的支配。

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本文引用的文献

1
Monozygotic and dizygotic twin diagnosis.单卵双胎和双卵双胎诊断。
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Mode of inheritance of decreased C3b receptors on erythrocytes of patients with systemic lupus erythematosus.系统性红斑狼疮患者红细胞上C3b受体减少的遗传方式。
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Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus.系统性红斑狼疮患者红细胞中的补体受体（CR1）缺陷。
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Primate erythrocyte-immune complex-clearing mechanism.灵长类动物红细胞免疫复合物清除机制。
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A new solid-state reagent to iodinate proteins. I. Conditions for the efficient labeling of antiserum.一种用于蛋白质碘化的新型固态试剂。I. 高效标记抗血清的条件。
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Low C3b receptor reactivity on erythrocytes from patients with systemic lupus erythematosus detected by immune adherence hemagglutination and radioimmunoassays with monoclonal antibody.通过免疫粘附血凝和单克隆抗体放射免疫测定法检测系统性红斑狼疮患者红细胞上低C3b受体反应性。
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The isolation of IgG from mammalian sera with the aid of caprylic acid.借助辛酸从哺乳动物血清中分离免疫球蛋白G
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Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation.系统性红斑狼疮及其他涉及自身抗体和/或补体激活的疾病患者中与疾病相关的红细胞补体受体（CR1，C3b受体）缺失。
J Immunol. 1985 Sep;135(3):2005-14.

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