Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Braz J Med Biol Res. 2021 Oct 29;54(12):e11521. doi: 10.1590/1414-431X2021e11521. eCollection 2021.
Visceral adipose tissue (VAT) is associated with various metabolic disorders, and adipokines, secreted by adipose tissue, are involved in their pathogenesis. This study investigated associations between VAT/subcutaneous adipose tissue (SAT) ratio, inflammatory markers, and cardiovascular (CV) risk-score in adults. Plasma levels of adipokines, plasma lipid profile, blood pressure, and body composition (using dual-emission x-ray absorptiometry) were determined. CV risk-score based on the American College of Cardiology and the American Heart Association (ACC/AHA) score was calculated in a sample of 309 Brazilian civil servants aged <60 years. Participants' VAT/SAT ratio were categorized into quartiles. Among males, plasma leptin (2.8 ng/mL) and C reactive protein (CRP) (0.2 mg/dL) (P<0.05) levels were higher at P75 and P50 than P5, and the highest calculated CV risk-score was observed at P75 (7.1%). Among females, higher plasma adiponectin levels were observed at P25 (54.3 ng/mL) compared with P75 (36 ng/mL) (P<0.05). Higher plasma CRP levels were observed at P75 (0.4 mg/dL) compared with P5 (0.1 mg/dL) (P<0.05). Higher CV risk-score was observed at P75 (2.0%) compared with P5 (0.7%). In both sexes, VAT and VAT/SAT ratio were directly associated with plasma leptin, CRP, and CV risk-score, and inversely associated with adiponectin; SAT was directly associated with plasma leptin and CRP (P<0.01); interleukin (IL)-10 and CRP were directly associated with adiponectin and leptin, respectively (P<0.05). Among men only, IL-10 (inversely) and CRP (directly) were associated with CV risk-score (P=0.02). Our results strengthened the relevance of the VAT/SAT ratio in cardiovascular risk.
内脏脂肪组织（VAT）与各种代谢紊乱有关，脂肪组织分泌的脂肪因子参与其发病机制。本研究调查了成人 VAT/皮下脂肪组织（SAT）比值、炎症标志物与心血管（CV）风险评分之间的关系。测定了脂肪因子的血浆水平、血脂谱、血压和身体成分（使用双能 X 射线吸收法）。在 309 名年龄<60 岁的巴西公务员样本中计算了基于美国心脏病学会和美国心脏协会（ACC/AHA）评分的 CV 风险评分。参与者的 VAT/SAT 比值分为四组。在男性中，血浆瘦素（2.8ng/mL）和 C 反应蛋白（CRP）（0.2mg/dL）（P<0.05）水平在 P75 和 P50 时高于 P5，最高计算的 CV 风险评分在 P75 时观察到（7.1%）。在女性中，P25 时的血浆脂联素水平（54.3ng/mL）高于 P75（36ng/mL）（P<0.05）。P75 时的血浆 CRP 水平（0.4mg/dL）高于 P5（0.1mg/dL）（P<0.05）。P75 时的 CV 风险评分（2.0%）高于 P5（0.7%）。在男性和女性中，VAT 和 VAT/SAT 比值与血浆瘦素、CRP 和 CV 风险评分呈直接相关，与脂联素呈负相关；SAT 与血浆瘦素和 CRP 呈直接相关（P<0.01）；白细胞介素（IL）-10 和 CRP 分别与脂联素和瘦素呈直接相关（P<0.05）。仅在男性中，IL-10（反向）和 CRP（直接）与 CV 风险评分相关（P=0.02）。我们的研究结果加强了 VAT/SAT 比值在心血管风险中的相关性。
