微小RNA-545在上皮性卵巢癌中的潜在抑癌作用
Potential tumor suppressing role of microRNA-545 in epithelial ovarian cancer.
作者信息
Jia Xibiao, Liu Xiaogang, Li Ming, Zeng Yu, Feng Zaoming, Su Xian, Huang Yan, Chen Maomao, Yang Xueyi
机构信息
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Department of Obstetrics and Gynaecology, People's Hospital of Yuxi, Yuxi, Yunnan 653100, P.R. China.
出版信息
Oncol Lett. 2018 May;15(5):6386-6392. doi: 10.3892/ol.2018.8130. Epub 2018 Feb 27.
Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer, which exhibits invasive traits. MicroRNAs (miRNAs/miRs) have been demonstrated to serve important functions in the pathogenesis of EOC. However, the function of miR-545 in EOC remains unknown. In the present study, the function of miR-545 in EOC was analyzed and it was identified that miR-545 is downregulated in EOC tissues and cell lines. Additionally, a low level of miR-545 expression was associated with a low survival rate of patients with EOC. Furthermore, overexpression of miR-545 inhibited cell growth and promoted apoptosis. Suppression of miR-545 promoted cell growth and inhibited apoptosis. Additionally, the RAC-γ serine/threonine-protein kinase gene was targeted by miR-545. Thus, it may be concluded that miR-545 exhibited antitumor traits in EOC.
上皮性卵巢癌（EOC）是最常见的卵巢癌类型，具有侵袭性特征。微小RNA（miRNA/miR）已被证明在EOC的发病机制中发挥重要作用。然而，miR-545在EOC中的功能仍不清楚。在本研究中，分析了miR-545在EOC中的功能，发现miR-545在EOC组织和细胞系中表达下调。此外，miR-545低表达与EOC患者低生存率相关。此外，miR-545过表达抑制细胞生长并促进细胞凋亡。抑制miR-545则促进细胞生长并抑制细胞凋亡。此外，RAC-γ丝氨酸/苏氨酸蛋白激酶基因是miR-545的靶标。因此，可以得出结论，miR-545在EOC中表现出抗肿瘤特性。
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