Streit Andrea
Centre for Craniofacial and Regenerative Biology, Division of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, London UK.
Int J Dev Biol. 2018;62(1-2-3):195-205. doi: 10.1387/ijdb.170298as.
Sensory placodes contribute to much of the sensory nervous system in the vertebrate head. They give rise to parts of the eye, ear and nose, as well as to the sensory ganglia that innervate the face, tongue, oesophagus and visceral tissues. Despite their diversity, during development placodes arise from a population of common progenitor cells, which are first specified at the border of the neural plate. The chick has been particularly instrumental in dissecting the timing of these events, and recent evidence has highlighted the close relationship of placode progenitors and precursors for neural crest cells and the central nervous system. This review focuses on the induction of placode progenitors by localised signalling events, and the transcriptional networks that lead to their specification.
感觉基板对脊椎动物头部的大部分感觉神经系统都有贡献。它们产生眼睛、耳朵和鼻子的部分结构，以及支配面部、舌头、食道和内脏组织的感觉神经节。尽管它们具有多样性，但在发育过程中，基板起源于一群共同的祖细胞，这些祖细胞最初在神经板的边界处被指定。鸡在剖析这些事件的时间方面发挥了特别重要的作用，最近的证据突出了基板祖细胞与神经嵴细胞和中枢神经系统前体细胞之间的密切关系。本综述重点关注局部信号事件对基板祖细胞的诱导，以及导致其特化的转录网络。
