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扩大青少年和青年男性自愿医学性割礼规模以预防人类免疫缺陷病毒:选定国家实施和影响的建模分析。

Scaling Up Voluntary Medical Male Circumcision for Human Immunodeficiency Virus Prevention for Adolescents and Young Adult Men: A Modeling Analysis of Implementation and Impact in Selected Countries.

机构信息

Office of HIV/AIDS, Global Health Bureau, United States Agency for International Development, Washington, District of Columbia.

Independent Consultant, Geneva, Switzerland.

出版信息

Clin Infect Dis. 2018 Apr 3;66(suppl_3):S166-S172. doi: 10.1093/cid/cix969.

Abstract

BACKGROUND

The new World Health Organization and Joint United Nations Programme on HIV/AIDS strategic framework for voluntary medical male circumcision (VMMC) aims to increase VMMC coverage among males aged 10-29 years in priority settings to 90% by 2021. We use mathematical modeling to assess the likelihood that selected countries will achieve this objective, given their historical VMMC progress and current implementation options.

METHODS

We use the Decision Makers' Program Planning Toolkit, version 2, to examine 4 ambitious but feasible scenarios for scaling up VMMC coverage from 2017 through 2021, inclusive in Lesotho, Malawi, Mozambique, Namibia, South Africa, Swaziland, Tanzania, Uganda, and Zimbabwe.

RESULTS

Tanzania is the only country that would reach the goal of 90% VMMC coverage in 10- to 29-year-olds by the end of 2021 in the scenarios assessed, and this was true in 3 of the scenarios studied. Mozambique, South Africa, and Lesotho would come close to reaching the objective only in the most ambitious scenario examined.

CONCLUSIONS

Major changes in VMMC implementation in most countries will be required to increase the proportion of circumcised 10- to 29-year-olds to 90% by the end of 2021. Scaling up VMMC coverage in males aged 10-29 years will require significantly increasing the number of circumcisions provided to 10- to 14-year-olds and 15- to 29-year-olds.

摘要

背景

世界卫生组织和联合国艾滋病规划署新的自愿男性包皮环切战略框架旨在到 2021 年将 10-29 岁男性中接受包皮环切的人数比例在重点地区提高到 90%。我们使用数学模型评估了在考虑到各国历史上包皮环切进展情况和当前实施选择的情况下,这些国家实现这一目标的可能性。

方法

我们使用决策者规划工具包 2.0 版本,审查了在 2017 年至 2021 年期间扩大包皮环切覆盖范围的 4 种雄心勃勃但可行的方案,包括莱索托、马拉维、莫桑比克、纳米比亚、南非、斯威士兰、坦桑尼亚、乌干达和津巴布韦。

结果

在评估的方案中,坦桑尼亚是唯一一个到 2021 年底将 10-29 岁男性中接受包皮环切的人数比例提高到 90%的国家,在研究的 3 个方案中也是如此。只有在最具野心的方案中,莫桑比克、南非和莱索托才接近于实现这一目标。

结论

大多数国家需要对包皮环切的实施进行重大改变,才能在 2021 年底前将 10-29 岁男性中接受包皮环切的比例提高到 90%。要想提高 10-29 岁男性的包皮环切覆盖范围,就需要显著增加为 10-14 岁和 15-29 岁男性提供的包皮环切数量。

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