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非冷冻象鼻技术用于Stanford A型急性主动脉夹层全弓置换的长期疗效

Long-term outcomes of total arch replacement with the non-frozen elephant trunk technique for Stanford Type A acute aortic dissection.

作者信息

Inoue Yosuke, Matsuda Hitoshi, Omura Atsushi, Seike Yoshimasa, Uehara Kyokun, Sasaki Hiroaki, Kobayashi Junjiro

机构信息

Department of Cardiovascular surgery, National Cerebral and Cardiovascular Center, Suita, Japan.

出版信息

Interact Cardiovasc Thorac Surg. 2018 Sep 1;27(3):455-460. doi: 10.1093/icvts/ivy094.

Abstract

OBJECTIVES

Arch repair using the frozen elephant trunk (FET) technique has been utilized to treat Type A acute aortic dissection. In contrast, the long-term outcomes of the non-FET technique focus on the thrombosed false lumen (FL), and distal aortic reoperation rates remain unclear. The goal of our study was to investigate the efficacy and long-term outcomes of the non-FET technique as the benchmark.

METHODS

We reviewed 518 patients with Type A acute aortic dissection in the last 20 years. Among them, 139 hospital survivors (61 ± 12 years) who had undergone total arch replacement with the non-FET technique were enrolled. A total of 86% (120/139) of patients had a patent FL at the descending aorta preoperatively. The median follow-up period was 41 (1-219) months.

RESULTS

No spinal cord ischaemia and new entry tear formation were observed. Postoperative FL thrombosis of the entire descending aorta was obtained in 47% (66/139) and in 39% (47/120) of patients who had a patent FL preoperatively. Freedom from dissection-related distal reoperation rates at 1, 3, 5 and 10 years were 87%, 83%, 81% and 78%, respectively. The results of multivariate analysis indicated that the predictors of a dissection-related reoperation were connective tissue disease [hazard ratio (HR) 4.6, P = 0.006], re-entry at the superior mesenteric artery (HR 2.9, P = 0.04), unachieved primary entry resection (HR 5.3, P = 0.001) and preoperative maximum descending aortic diameter ≥38 mm (HR 11.6, P < 0.001).

CONCLUSIONS

Total arch replacement with the non-FET technique was safe and reliable from the viewpoint of spinal cord ischaemia. Further comparative studies between the FET and the non-FET techniques are required.

摘要

目的

采用冰冻象鼻(FET)技术进行主动脉弓修复已被用于治疗A型急性主动脉夹层。相比之下,非FET技术的长期疗效主要关注血栓形成的假腔(FL),而远端主动脉再次手术率仍不明确。我们研究的目的是将非FET技术作为基准,调查其疗效和长期预后。

方法

我们回顾了过去20年中518例A型急性主动脉夹层患者。其中,139例采用非FET技术进行全主动脉弓置换的医院幸存者(61±12岁)被纳入研究。术前,共有86%(120/139)的患者降主动脉处FL通畅。中位随访期为41(1-219)个月。

结果

未观察到脊髓缺血和新的入口撕裂形成。术前FL通畅的患者中,47%(66/139)和39%(47/120)的患者术后降主动脉全程FL血栓形成。1年、3年、5年和10年时与夹层相关的远端再次手术率分别为87%、83%、81%和78%。多因素分析结果表明,与夹层相关再次手术的预测因素为结缔组织病[风险比(HR)4.6,P=0.006]、肠系膜上动脉再入口(HR 2.9,P=0.04)、未完成初次入口切除(HR 5.3,P=0.001)以及术前降主动脉最大直径≥38 mm(HR 11.6,P<0.001)。

结论

从脊髓缺血的角度来看,采用非FET技术进行全主动脉弓置换是安全可靠的。FET技术和非FET技术之间需要进一步的对比研究。

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