表型模拟器：一种用于模拟多性状、多基因座基因型与表型关系的综合框架。
PhenotypeSimulator: A comprehensive framework for simulating multi-trait, multi-locus genotype to phenotype relationships.
机构信息
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
出版信息
Bioinformatics. 2018 Sep 1;34(17):2951-2956. doi: 10.1093/bioinformatics/bty197.
MOTIVATION
Simulation is a critical part of method development and assessment. With the increasing sophistication of multi-trait and multi-locus genetic analysis techniques, it is important that the community has flexible simulation tools to challenge and explore the properties of these methods.
RESULTS
We have developed PhenotypeSimulator, a comprehensive phenotype simulation scheme that can model multiple traits with multiple underlying genetic loci as well as complex covariate and observational noise structure. This package has been designed to work with many common genetic tools both for input and output. We describe the underlying components of this simulation tool and illustrate its use on an example dataset.
AVAILABILITY AND IMPLEMENTATION
PhenotypeSimulator is available as a well documented R/CRAN package and the code is available on github: https://github.com/HannahVMeyer/PhenotypeSimulator.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
动机
模拟是方法开发和评估的关键部分。随着多性状和多基因座遗传分析技术的日益复杂，社区拥有灵活的模拟工具来挑战和探索这些方法的特性非常重要。
结果
我们开发了 PhenotypeSimulator，这是一种综合的表型模拟方案，可对具有多个潜在遗传基因座的多个性状进行建模，以及复杂的协变量和观测噪声结构。该软件包旨在与许多常见的遗传工具配合使用，无论是输入还是输出。我们描述了这个模拟工具的基本组件，并在一个示例数据集上演示了它的用法。
可用性和实现
PhenotypeSimulator 是一个有详细文档记录的 R/CRAN 包，代码可在 github 上获得：https://github.com/HannahVMeyer/PhenotypeSimulator。
补充信息
补充数据可在 Bioinformatics 在线获得。
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