Sagar K B, Hastillo A, Wolfgang T C, Lower R R, Hess M L
Circulation. 1981 Aug;64(2 Pt 2):II217-20.
Serial determination of left ventricular mass, right ventricular and left atrial size, fractional shortening and left ventricular systolic time intervals were made from M-mode echocardiograms in 13 long-term survivors with cardiac allografts These measurements were correlated with presence or absence of acute rejection as determined by myocardial biopsy. Left ventricular mass increased significantly, from a baseline of 129.8 +/- 11.8 (mean +/- SEM) to 310.5 +/- 13.0 g during 12 episodes of rejection. In contrast during eight episodes without rejection, the left ventricular mass did not increase significantly (baseline 175.2 +/- 11.8 to 211.9 +/- 25.6 g). There was no relationship between changes in right ventricular and left atrial size, fractional shortening or systolic time intervals and presence or absence of rejection of myocardial biopsy. An increase in left ventricular mass by M-mode echocardiography offers a reliable noninvasive method for detection of acute rejection of a cardiac allograft.
对13例心脏移植长期存活者的M型超声心动图进行了左心室质量、右心室和左心房大小、缩短分数及左心室收缩时间间期的系列测定。这些测量结果与经心肌活检确定的急性排斥反应的有无相关。在12次排斥反应发作期间，左心室质量显著增加，从基线的129.8±11.8（均值±标准误）克增至310.5±13.0克。相比之下，在8次无排斥反应发作期间，左心室质量没有显著增加（基线为175.2±11.8克至211.9±25.6克）。右心室和左心房大小、缩短分数或收缩时间间期的变化与心肌活检排斥反应的有无之间没有关系。通过M型超声心动图检测左心室质量增加，为心脏移植急性排斥反应的检测提供了一种可靠的非侵入性方法。
