Department of Ophthalmology, Keio University School of Medicine.
Department of Neuropsychiatry, Keio University School of Medicine.
J Occup Health. 2018 Jul 25;60(4):281-288. doi: 10.1539/joh.2017-0191-OA. Epub 2018 Apr 4.
To evaluate the effects of a 2-month lifestyle intervention for dry eye disease in office workers.
Prospective interventional study (randomized controlled study). Forty-one middle-aged Japanese office workers (men, 22; women, 19; 39.2±8.0 years) with definite and probable dry eye disease were enrolled and randomized to an intervention group (n = 22) and a control group (n = 19). The intervention aimed at modifying diet, increasing physical activity, and encouraging positive thinking. The primary outcome was change in dry eye disease diagnoses. Secondary outcome was change in disease parameters, including dry eye symptoms, as assessed using the Dry Eye-Related Quality of Life Score, corneal and conjunctival staining scores, tear break-up time, and Schirmer test results.
A total of 36 participants (intervention group, 17; control group, 19) completed the study. The number of definite dry eye disease diagnoses decreased from four to none (p =.05), and the dry eye symptom score showed a significant decrease in the intervention group (p =.03). In contrast, the corneal and conjunctival staining scores, tear break-up time, and Schirmer test results did not differ significantly between groups.
The 2-month lifestyle intervention employed in this study improved dry eye disease status among office workers, with a considerable decrease in subjective symptoms. Lifestyle intervention may be a promising management option for dry eye disease, although further investigation of long-term effects are required.
评估为期 2 个月的生活方式干预对办公室工作人员干眼症的影响。
前瞻性干预研究（随机对照研究）。共纳入 41 名中年日本上班族（男性 22 名，女性 19 名；39.2±8.0 岁），均患有明确和可能的干眼症，并随机分为干预组（n=22）和对照组（n=19）。干预措施旨在改变饮食、增加身体活动和鼓励积极思考。主要结局是干眼症的诊断变化。次要结局是疾病参数的变化，包括使用干眼相关生活质量评分评估的干眼症状、角膜和结膜染色评分、泪膜破裂时间和 Schirmer 测试结果。
共有 36 名参与者（干预组 17 名，对照组 19 名）完成了研究。明确干眼症的诊断数量从 4 例减少到 0 例（p=.05），干预组的干眼症状评分显著下降（p=.03）。相比之下，角膜和结膜染色评分、泪膜破裂时间和 Schirmer 测试结果在组间无显著差异。
本研究中采用的为期 2 个月的生活方式干预改善了上班族的干眼症状况，主观症状显著减轻。生活方式干预可能是干眼症的一种有前途的管理选择，但需要进一步研究长期效果。
