用于次氯酸成像的基于脱甲酰基反应的探针。
Deformylation reaction-based probe for imaging of HOCl.
作者信息
Wei Peng, Yuan Wei, Xue Fengfeng, Zhou Wei, Li Ruohan, Zhang Datong, Yi Tao
机构信息
Department of Chemistry , Collaborative Innovation Center of Chemistry for Energy Materials , Fudan University , 220 Handan Road , Shanghai 200433 , China . Email:
Shandong Provincial Key Laboratory of Fine Chemicals , School of Chemistry and Pharmaceutical Engineering , Qilu University of Technology , Jinan 250353 , Shandong , China.
出版信息
Chem Sci. 2017 Nov 3;9(2):495-501. doi: 10.1039/c7sc03784h. eCollection 2018 Jan 14.
The detection of hypochlorous acid (HOCl) is vitally important because the local concentration of HOCl is highly correlated with some diseases such as atherosclerosis and rheumatoid arthritis. However, detection of HOCl remains a challenge due to the lack of a suitable probe. We report here a near-infrared (NIR) emissive "turn-on" probe () based on a methylene blue derivative, which can quickly detect HOCl a newly found deformylation mechanism. displays remarkable selectivity and sensitivity towards HOCl. The dramatic changes in colour and NIR emission were used to detect HOCl and in a mouse arthritis model.
次氯酸（HOCl）的检测至关重要，因为HOCl的局部浓度与动脉粥样硬化和类风湿性关节炎等一些疾病高度相关。然而，由于缺乏合适的探针，HOCl的检测仍然是一项挑战。我们在此报告一种基于亚甲蓝衍生物的近红外（NIR）发射型“开启”探针（），它可以通过一种新发现的脱甲酰化机制快速检测HOCl。该探针对HOCl具有显著的选择性和灵敏度。利用颜色和近红外发射的显著变化在小鼠关节炎模型中检测HOCl和。
Zotero 插件