近年来用于检测活性氧和氮物种的荧光、发光和比色探针的发展进展。

Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species.

机构信息

Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Korea.

出版信息

Chem Soc Rev. 2016 May 21;45(10):2976-3016. doi: 10.1039/c6cs00192k. Epub 2016 Apr 19.

Abstract

Reactive oxygen (ROS) and nitrogen (RNS) species cause oxidative and nitrosative stresses, respectively. These stresses are implicated not only in diverse physiological processes but also in various pathological processes, including cancer and neurodegenerative disorders. In addition, some ROS and RNS in the environment are pollutants that threaten human health. As a consequence of these effects, sensitive methods, which can be employed to selectively monitor ROS and RNS in live cells, tissues and organisms as well as in environmental samples, are needed so that their biological roles can be understood and their concentrations in environmental samples can be determined. In this review, fluorescent, luminescent and colorimetric ROS and RNS probes, which have been developed since 2011, are comprehensively discussed.

摘要

活性氧（ROS）和活性氮（RNS）物种分别导致氧化应激和硝化应激。这些应激不仅与各种生理过程有关，而且与各种病理过程有关，包括癌症和神经退行性疾病。此外，环境中的一些 ROS 和 RNS 是威胁人类健康的污染物。由于这些影响，需要使用能够选择性地监测活细胞、组织和生物体以及环境样品中的 ROS 和 RNS 的敏感方法，以便了解它们的生物学作用并确定环境样品中的浓度。在这篇综述中，全面讨论了自 2011 年以来开发的荧光、发光和比色 ROS 和 RNS 探针。