Centre for Observational Research and Data Sciences, Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.
Real-World Evidence, Evidera, London, W6 8DL, UK.
Eur J Epidemiol. 2018 Jun;33(6):601-605. doi: 10.1007/s10654-018-0389-5. Epub 2018 Apr 4.
The Clinical Practice Research Datalink (CPRD) is a repository of electronic medical records collected during routine primary care clinical practice in the UK, and is one of the most widely used sources of real-world data for healthcare research. Although CPRD provides access to comprehensive longitudinal patient records, the data does not fully capture diagnoses or outcomes occurring in secondary care and/or mortality. We provide here an overview of CPRD and the potential bias when using unlinked data in certain situations. Linkage of CPRD to other datasets can help to overcome these limitations. We discuss when to consider linkage to secondary care, disease-specific data sources or the official mortality data when conducting research using CPRD data.
临床实践研究数据库（CPRD）是英国常规初级保健临床实践中收集的电子病历存储库，是用于医疗保健研究的最广泛使用的真实世界数据来源之一。尽管 CPRD 提供了对全面纵向患者记录的访问，但这些数据并不能完全捕捉到二级保健和/或死亡率中发生的诊断或结果。在这里，我们概述了 CPRD 以及在某些情况下使用未链接数据时可能存在的偏差。CPRD 与其他数据集的链接有助于克服这些限制。我们讨论了在使用 CPRD 数据进行研究时何时考虑与二级保健、特定疾病数据源或官方死亡率数据进行链接。
