Umapathi Reddicherla, Reddy P Madhusudhana, Rani Anjeeta, Venkatesu Pannuru
Department of Chemistry, University of Delhi, Delhi-110 007, India.
Phys Chem Chem Phys. 2018 Apr 18;20(15):9717-9744. doi: 10.1039/c7cp08172c.
Thermoresponsive polymers (TRPs) in different solvent media have been studied over a long period and are important from both scientific and technical points of view. Despite numerous studies on the behavior of TRPs with various additives, the interactions of additives with TRPs are still poorly understood. Moreover, despite the vast available literature regarding the biomolecular interactions between various TRPs and naturally occurring additives, it is not possible to provide a unifying declaration about the behavior of different additives, in particular at the phase transition temperature of the polymer. However, potential reviews that describe the behavior of additives as stimuli upon the phase transition of TRPs are also absent. A lack of sufficient knowledge regarding the responses of TRPs to additives as stimuli has hindered the expansion of the wide spectrum of applications of these polymers. Therefore, it was proposed to review the responses of TRPs in the presence of various additives in aqueous media. In-depth knowledge acquired via a literature survey has drawn our attention towards filling this gap by analyzing the interactions of TRPs with different additives. In this perspective, we have systematically examined the stability, aggregation, and phase transition behaviours of various polymers in the presence of different additives. The perspective on the influence of additives as stimuli on the behavior of TRPs in an aqueous medium will provide new reliable information about intramolecular interactions between interior polymer segments as well as intermolecular interactions between TRPs and additive molecules, which will be helpful for industrialists in the preparation of new polymeric materials for drug-delivery systems.
长期以来，人们一直在研究不同溶剂介质中的热响应性聚合物（TRP），从科学和技术角度来看，它们都很重要。尽管对添加各种添加剂的TRP行为进行了大量研究，但添加剂与TRP之间的相互作用仍未得到充分理解。此外，尽管有大量关于各种TRP与天然存在的添加剂之间生物分子相互作用的文献，但对于不同添加剂的行为，尤其是在聚合物的相变温度下，仍无法给出统一的说明。然而，也缺乏描述添加剂作为TRP相变刺激因素行为的潜在综述。对TRP对添加剂作为刺激因素的响应缺乏足够的了解，阻碍了这些聚合物广泛应用的拓展。因此，有人提议综述TRP在水性介质中存在各种添加剂时的响应。通过文献调研获得的深入知识，使我们注意到通过分析TRP与不同添加剂的相互作用来填补这一空白。从这个角度出发，我们系统地研究了各种聚合物在不同添加剂存在下的稳定性、聚集和相变行为。添加剂作为刺激因素对水性介质中TRP行为影响的观点，将为聚合物内部链段之间的分子内相互作用以及TRP与添加剂分子之间的分子间相互作用提供新的可靠信息，这将有助于实业家制备用于药物递送系统的新型高分子材料。
