Zawdie Belay, Tadesse Samuel, Wolide Amare Desalegn, Nigatu Tilahun Alemayehu, Bobasa Eshetu Mulisa
School of Biomedical Sciences, Faculty of Medical Sciences, Jimma University.
School of Pharmacy, Faculty of Health Sciences, Jimma University.
Ethiop J Health Sci. 2018 Jan;28(1):19-30. doi: 10.4314/ejhs.v28i1.4.
Non-alcoholic Fatty Liver Disease (NAFLD) among type 2 diabetic patients is completely ignored in developing regions like Africa paving the way for public health and economic burden in the region. Therefore, the main objective of this research was to evaluate non-alcoholic fatty liver disease and associated factors among type 2 diabetic patients in Southwestern Ethiopia attending Diabetic Clinic of Jimma University Specialized Hospital (JUSH).
Facility based cross-sectional study design was used. Anthropometry, fatty liver (using utrasonography), liver enzymes, and lipid profiles were measured among type 2 diabetic patients who fulfilled the inclusion criteria. Socio-demographic and clinical characteristics were assessed using standard questionnaires.
Ninety-six (96) type 2 diabetic patients were enrolled and non-alcoholic fatty liver disease prevalence was 73%. Of non-alcoholic fatty Liver disease documented patients, 35.4%, 31.3% and 6.3% exhibited mild, moderate and severe fatty liver diseases, respectively. Alanine aminotransferase (p ≤0.001), Triacyglycerol (p ≤0.001), total bilirubin (p ≤0.05), direct bilirubin (p ≤0.05) and diabetic duration (p ≤0.01) were significantly associated with non-alcoholic fatty liver disease among type 2 diabetic patients. The Aspartate aminotransferase/Alanine aminotransferase ratio among non alcoholic fatty liver disease patients was greater than one.
The magnitude of non-alcoholic fatty liver disease is high among study groups and it needs urgent action by healthcare systems. Therefore, targeted treatment approach inclusive of non-alcoholic fatty liver disease should be designed.
在非洲等发展中地区，2型糖尿病患者中的非酒精性脂肪性肝病（NAFLD）完全被忽视，这为该地区带来了公共卫生和经济负担。因此，本研究的主要目的是评估在吉马大学专科医院（JUSH）糖尿病诊所就诊的埃塞俄比亚西南部2型糖尿病患者中的非酒精性脂肪性肝病及相关因素。
采用基于机构的横断面研究设计。对符合纳入标准的2型糖尿病患者进行人体测量、脂肪肝（使用超声检查）、肝酶和血脂谱检测。使用标准问卷评估社会人口统计学和临床特征。
纳入了96例2型糖尿病患者，非酒精性脂肪性肝病患病率为73%。在记录有非酒精性脂肪性肝病的患者中，分别有35.4%、31.3%和6.3%表现为轻度、中度和重度脂肪肝疾病。丙氨酸转氨酶（p≤0.001）、甘油三酯（p≤0.001）、总胆红素（p≤0.05）、直接胆红素（p≤0.05）和糖尿病病程（p≤0.01）与2型糖尿病患者的非酒精性脂肪性肝病显著相关。非酒精性脂肪性肝病患者的天冬氨酸转氨酶/丙氨酸转氨酶比值大于1。
研究组中非酒精性脂肪性肝病的发生率很高，医疗系统需要紧急采取行动。因此，应设计包括非酒精性脂肪性肝病在内的靶向治疗方法。
