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幼儿期接触液态甜味剂:4 - 5岁时人工甜味饮料和含糖饮料的摄入量与7 - 8岁时超重和肥胖风险的关系

Exposure to liquid sweetness in early childhood: artificially-sweetened and sugar-sweetened beverage consumption at 4-5 years and risk of overweight and obesity at 7-8 years.

作者信息

Macintyre A K, Marryat L, Chambers S

机构信息

Centre for Health Policy, University of Strathclyde, Glasgow, UK.

Farr Institute Scottish Collaboration for Public Health Research and Policy, University of Edinburgh, Edinburgh, UK.

出版信息

Pediatr Obes. 2018 Dec;13(12):755-765. doi: 10.1111/ijpo.12284. Epub 2018 Apr 6.

Abstract

BACKGROUND

A significant gap exists in longitudinal evidence on early exposure to artificially sweetened beverages (ASBs) and weight outcomes for paediatric populations.

OBJECTIVE

The objective of this study is to examine the relationship between ASB/sugar-sweetened beverage (SSB) consumption at 4-5 years and risk of overweight and obesity at 7-8 years.

METHODS

Data from a nationally representative cohort (n = 2986) in Scotland were analysed using logistic regression to evaluate the association between exposure to ASBs/SSBs at 4-5 years and risk of overweight and obesity at 7-8 years.

RESULTS

There were positive unadjusted associations between ASB consumption and risk of obesity, and following adjustment for confounders, ASB associations attenuated, and only the middle consumption category (1 to 6 times per week) remained significant (odds ratio 1.57, 95% confidence interval {CI} 1.05-2.36). For SSB consumption, there were no significant unadjusted associations, and following adjustment for confounders, only the middle consumption category was significant (odds ratio 1.65, 95% CI 1.12-2.44). There were no significant associations for risk of overweight.

CONCLUSIONS

Longitudinal analysis from 4-5 to 7-8 years demonstrated some evidence of associations between ASBs/SSB consumption and risk of obesity. However, non-linear patterns and wide CIs suggest cautious interpretation and need for future studies with long-term follow-up.

摘要

背景

关于儿童早期接触人工甜味饮料(ASB)及其体重结果的纵向证据存在显著差距。

目的

本研究的目的是探讨4至5岁时ASB/含糖甜味饮料(SSB)的摄入量与7至8岁时超重和肥胖风险之间的关系。

方法

对苏格兰一个具有全国代表性的队列(n = 2986)的数据进行逻辑回归分析,以评估4至5岁时接触ASB/SSB与7至8岁时超重和肥胖风险之间的关联。

结果

ASB摄入量与肥胖风险之间存在未经调整的正相关,在对混杂因素进行调整后,ASB的关联减弱,只有中等摄入量类别(每周1至6次)仍然显著(优势比1.57,95%置信区间{CI} 1.05 - 2.36)。对于SSB摄入量,未经调整的关联不显著,在对混杂因素进行调整后,只有中等摄入量类别显著(优势比1.65,95% CI 1.12 - 2.44)。超重风险没有显著关联。

结论

4至5岁到7至8岁的纵向分析表明,有一些证据显示ASB/SSB摄入量与肥胖风险之间存在关联。然而,非线性模式和较宽的置信区间表明需要谨慎解读,并需要进行长期随访的未来研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6526/6492200/b03ae723624a/IJPO-13-755-g001.jpg

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