女贞果实中的裂环环烯醚萜类似物及其对甲型流感病毒的抑制活性。

Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus.

作者信息

Pang Xu, Zhao Jian-Yuan, Yu Hai-Yang, Yu Li-Yan, Wang Tao, Zhang Yi, Gao Xiu-Mei, Han Li-Feng

机构信息

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

出版信息

Bioorg Med Chem Lett. 2018 May 15;28(9):1516-1519. doi: 10.1016/j.bmcl.2018.03.080. Epub 2018 Mar 30.

DOI:10.1016/j.bmcl.2018.03.080

PMID:29625823

Abstract

A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence, of which 1, 2, 4 (ligulucisides A-C), 10 and 11 (liguluciridoids A and B) were identified as new secoiridoid analogues. An in vitro antiviral bioassay indicated that 1, 4, 6, and 10 displayed the inhibitory activities against influenza A virus with the IC values of 16.5, 12.5, 13.1, and 18.5 μM, respectively, which were better than the positive control Ribavirin (IC 22.6 μM). .

摘要

对女贞果实中的裂环环烯醚萜类成分进行了植物化学研究，最终分离出9种裂环环烯醚萜苷（1 - 9）以及2种裂环环烯醚萜（10、11）。所有化合物的结构主要通过核磁共振（NMR）和质谱（MS）实验以及必要的化学证据得以确定，其中1、2、4（女贞苷A - C）、10和11（女贞裂环环烯醚萜A和B）被鉴定为新的裂环环烯醚萜类似物。体外抗病毒生物测定表明，1、4、6和10对甲型流感病毒具有抑制活性，其半数抑制浓度（IC）值分别为16.5、12.5、13.1和18.5 μM，优于阳性对照利巴韦林（IC 22.6 μM）。