用于伤口愈合应用的药物输送系统和材料。
Drug delivery systems and materials for wound healing applications.
机构信息
Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw 02-507, Poland.
出版信息
Adv Drug Deliv Rev. 2018 Mar 1;127:138-166. doi: 10.1016/j.addr.2018.04.008. Epub 2018 Apr 5.
Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.
慢性、难愈的伤口给患者和医疗系统带来了巨大的负担，导致活动受限、肢体截肢，甚至死亡。慢性伤口是由于伤口愈合过程中高度协调的一系列事件发生中断而导致的。我们对慢性伤口病理生理学的认识有了重大进展，开发了旨在针对受损过程不同方面的药物。然而，富含降解酶的伤口环境的恶劣性及其升高的 pH 值，加上组织再生涉及的不同生理过程的时间尺度的差异，都需要使用有效的药物输送系统。在这篇综述中，我们将首先讨论慢性伤口的病理生理学，然后讨论用于工程药物输送系统的材料。将回顾用于伤口护理的不同被动和主动药物输送系统。此外，还讨论了输送平台的架构及其调节药物输送的能力。还强调了新兴技术和为工程更有效的伤口护理设备提供的机会。
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