College of Resources and Environment, Key Laboratory of Agricultural Environment in Universities of Shandong, Shandong Agricultural University, 61 Daizong Road, Taian 271018, PR China.
Chemosphere. 2018 Jul;203:381-386. doi: 10.1016/j.chemosphere.2018.03.178. Epub 2018 Mar 27.
Ionic liquids (ILs) were considered new "green solvents" in consideration of the low volatility. Since their inception, ionic liquids (ILs) have attracted widespread attention. However, ILs were not safe enough as what we thought. The toxicity of 1-ethyl-3-methylimidazolium ILs ([Cmim]R, R = Cl, Br, BF) and 1-alkyl-3-methylimidazolium bromine ([Cmim]Br, n = 2, 4, 8, 10, 12) using 50% lethal concentration (LC) were studied in the present study to enrich the toxicological information. Besides the LC values, the sensitivity test using potassium dichromate (KCrO) and residue determinations of the tested ILs were also performed. The sensitivity and dynamic changes of IL doses both catered for the stipulation that declared the accuracy of the toxicological test results, which illustrated that the alkyl-chain lengths contributed more than anions to the toxicity of the ILs described above to zebrafish. Additionally, the present study also enriched the toxicological information on imidazolium-based ILs to aquatic systems.
离子液体 (ILs) 被认为是低挥发性的新型“绿色溶剂”。自问世以来，离子液体 (ILs) 引起了广泛关注。然而，离子液体并不像我们想象的那样安全。本研究用半数致死浓度 (LC) 研究了 1-乙基-3-甲基咪唑 ILs([Cmim]R，R = Cl，Br，BF)和 1-烷基-3-甲基咪唑溴 ([Cmim]Br，n = 2，4，8，10，12) 的毒性，以丰富毒理学信息。除了 LC 值外，还进行了使用重铬酸钾 (KCrO) 的敏感性测试和测试的 ILs 的残留量测定。IL 剂量的敏感性和动态变化都符合规定，即声明了毒理学测试结果的准确性，这表明烷基链长度对上述 ILs 对斑马鱼的毒性的贡献大于阴离子。此外，本研究还丰富了基于咪唑的 ILs 对水生系统的毒理学信息。
