Ge Xudong, Adangwa Prosper, Lim Ja Young, Kostov Yordan, Tolosa Leah, Pierson Richard, Herr Daniel, Rao Govind
Center for Advanced Sensor Technology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.
Center for Advanced Sensor Technology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.
Med Eng Phys. 2018 Jun;56:36-41. doi: 10.1016/j.medengphy.2018.03.009. Epub 2018 Apr 5.
Blood gas measurements provide vital clinical information in critical care. The current "gold standard" for blood gas measurements involves obtaining blood samples, which can be painful and can lead to bleeding, thrombus formation, or infection. Mass transfer equilibrium-based transcutaneous blood gas monitors have been used since the 1970s, but they require heating the skin to ≥42 °C to speed up the transcutaneous gas diffusion. Thus, these devices have a potential risk for skin burns. Here we report a new generation of noninvasive device for respiratory status assessment. Instead of waiting for mass transfer equilibrium, the blood gas levels are monitored by measuring the transcutaneous diffusion rate, which is proportional to blood gas concentration. The startup time of this device is almost independent of skin temperature, so the measurement can be made at any body temperature. The test results show that this device can track the blood gas levels quickly even at normal body temperature.
血气测量在重症监护中提供至关重要的临床信息。目前血气测量的“金标准”是采集血样，这可能会很痛苦，还可能导致出血、血栓形成或感染。自20世纪70年代以来，基于传质平衡的经皮血气监测仪就已被使用，但它们需要将皮肤加热到≥42°C以加速经皮气体扩散。因此，这些设备存在皮肤烧伤的潜在风险。在此，我们报告一种用于呼吸状态评估的新一代无创设备。该设备不是等待传质平衡，而是通过测量与血气浓度成正比的经皮扩散速率来监测血气水平。该设备的启动时间几乎与皮肤温度无关，因此可以在任何体温下进行测量。测试结果表明，即使在正常体温下，该设备也能快速追踪血气水平。
