Okunade Kehinde Sharafadeen, Nwogu Chidinma Magnus, Oluwole Ayodeji Ayotunde, Anorlu Rose Ihuoma
Department of Obstetrics & Gynaecology, Lagos University Teaching Hospital Lagos, Nigeria.
Department of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.
Pan Afr Med J. 2017 Nov 14;28:227. doi: 10.11604/pamj.2017.28.227.13979. eCollection 2017.
Cervical cancer is the second most common cancer among women in the developing countries and the seventh commonest cancer in the developed countries. Human papillomavirus (HPV) is now known to be the main factor in the aetiology of cervical cancer with over 99.7% of cases being associated with previous high risk HPV (hrHPV) infection. This study was aimed to determine the prevalence and risk factors for genital hrHPV infection among women attending the out-patient clinics of the Lagos University Teaching Hospital.
This was a cross-sectional study involving a total of 200 women. Questionnaires were administered to collect data such as sociodemographic, reproductive and sexual histories. Endocervical swab samples were then taken from each participant. Samples were analyzed by polymerase chain reaction (PCR) using consensus primers targeted against the hrHPV viruses.
The prevalence of hrHPV in the study was 36.5%. The most predominant HPV subtypes were 31 (25.0%), 35 (8.0%) and 16 (3.5%) with the largest proportion (76.1%) of the tested samples being positive for only a single hrHPV subtype. The study showed statistically significant associations between early age at coitarche (P = 0.032) and increasing number of lifetime sexual partners (P = 0.001) with genital hrHPV infection.
The prevalence of hrHPV was high in Lagos with the majority of test positive samples having only a single HPV genotype. We demonstrated early age of sexual debut and increasing number of lifetime sexual partners as the most important factors associated with genital hrHPV infection.
宫颈癌是发展中国家女性中第二常见的癌症，在发达国家则是第七常见的癌症。目前已知人乳头瘤病毒（HPV）是宫颈癌病因中的主要因素，超过99.7%的病例与既往高危型HPV（hrHPV）感染有关。本研究旨在确定在拉各斯大学教学医院门诊就诊的女性中生殖器hrHPV感染的患病率及危险因素。
这是一项横断面研究，共纳入200名女性。通过问卷调查收集社会人口统计学、生殖及性病史等数据。随后从每位参与者采集宫颈内拭子样本。使用针对hrHPV病毒的通用引物，通过聚合酶链反应（PCR）对样本进行分析。
本研究中hrHPV的患病率为36.5%。最主要的HPV亚型为31型（25.0%）、35型（8.0%）和16型（3.5%），76.1%的检测样本仅对单一hrHPV亚型呈阳性。该研究显示，初次性交年龄早（P = 0.032）及终身性伴侣数量增加（P = 0.001）与生殖器hrHPV感染之间存在统计学显著关联。
拉各斯的hrHPV患病率较高，大多数检测呈阳性的样本仅有一种HPV基因型。我们证明初次性行为年龄早及终身性伴侣数量增加是与生殖器hrHPV感染相关的最重要因素。
