Heck Michelle
USDA Agricultural Research Service, Emerging Pests and Pathogens Research Unit, Robert W. Holley Center for Agriculture and Health, Ithaca, New York, USA.
Boyce Thompson Institute, Ithaca, New York, USA.
mSystems. 2018 Mar 20;3(2). doi: 10.1128/mSystems.00168-17. eCollection 2018 Mar-Apr.
Insect-vectored pathogens pose one of the greatest threats to plant and animal, including human, health on a global scale. Few effective control strategies have been developed to thwart the transmission of any insect-transmitted pathogen. Most have negative impacts on the environment and human health and are unsustainable. Plant pathogen transmission by insect vectors involves a combination of coevolving biological players: plant hosts, insect vectors, plant pathogens, and bacterial endosymbionts harbored by the insect. Our ability to help growers to control vector-borne disease depends on our ability to generate pathogen- and/or disease-resistant crops by traditional or synthetic approaches and to block pathogen transmission by the insect vector. Systems biology studies have led to the reexamination of existing paradigms on how pathogens interact with insect vectors, including the bacterial symbionts, and have identified vector-pathogen interactions at the molecular and cellular levels for the development of novel transmission interdiction strategies.
在全球范围内，由昆虫传播的病原体对植物、动物（包括人类）的健康构成了最大威胁之一。目前几乎没有开发出有效的控制策略来阻止任何昆虫传播病原体的传播。大多数策略对环境和人类健康都有负面影响，而且不可持续。昆虫媒介传播植物病原体涉及多种共同进化的生物因素：植物宿主、昆虫媒介、植物病原体以及昆虫体内携带的细菌内共生体。我们帮助种植者控制媒介传播疾病的能力取决于我们通过传统或合成方法培育抗病原体和/或抗病作物的能力，以及阻止昆虫媒介传播病原体的能力。系统生物学研究促使人们重新审视关于病原体如何与昆虫媒介（包括细菌共生体）相互作用的现有范式，并在分子和细胞水平上确定了媒介与病原体的相互作用，以开发新的传播阻断策略。
