Nouri A M, Panayi G S
Rheumatology Unit, United Medical School Guy's Hospital, London England.
J Rheumatol. 1987 Oct;14(5):902-6.
Despite the evidence for activated T cells in the joint in rheumatoid arthritis (RA), there is evidence of deficient lymphocyte proliferation to a variety of stimulants. We investigated the production of interleukin-2 (IL-2) after phytohemagglutinin (PHA) stimulation. We show that in the peripheral blood IL-2 production was similar in RA and controls (3.7 vs 3.0 U/ml, respectively). However, blood lymphocytes from patients with joint effusions produced significantly less IL-2 than from patients without effusions (1.8 vs 5.7 U/ml, respectively). The amount of IL-2 produced by synovial fluids (SF) cells was significantly less than that produced by the corresponding blood cells (1.0 vs 1.6 U/ml). Further experiments revealed that the decreased IL-2 production was not due to its removal by IL-2 receptor positive cells in the SF and cell mixing experiments did not reveal any suppressor influences.
尽管有证据表明类风湿关节炎（RA）患者关节中的T细胞被激活，但也有证据显示淋巴细胞对多种刺激的增殖能力不足。我们研究了植物血凝素（PHA）刺激后白细胞介素-2（IL-2）的产生情况。我们发现，在类风湿关节炎患者和对照组中，外周血中IL-2的产生量相似（分别为3.7 U/ml和3.0 U/ml）。然而，有关节积液的患者血液淋巴细胞产生的IL-2明显少于无积液患者（分别为1.8 U/ml和5.7 U/ml）。滑膜液（SF）细胞产生的IL-2量明显少于相应血液细胞产生的量（分别为1.0 U/ml和1.6 U/ml）。进一步的实验表明，IL-2产生量的减少并非由于其被SF中IL-2受体阳性细胞清除，细胞混合实验也未显示出任何抑制作用。
