Combe B, Andary M, Klein B, Clot J, Sany J
J Rheumatol. 1987 Apr;14(2):226-9.
The regulation of interleukin-2 (IL-2) production was investigated using mononuclear cells from synovial fluid (SF) and peripheral blood of 12 patients with classical and active rheumatoid arthritis. Decreased phytohemagglutinin (PHA) stimulated IL-2 production by lymphocytes was observed in rheumatoid peripheral blood (5.3 +/- 10.9 units/ml) and SF (3.8 +/- 5.2 units/ml) compared to peripheral blood from 12 normal donors (18.1 +/- 15.4 units/ml) and SF from 5 patients with other rheumatic diseases (11.9 +/- 10.9 units/ml). Indomethacin, phorbol myristate acetate and irradiation of suppressor cells increased IL-2 values in rheumatoid SF and peripheral blood but did not restore normal IL-2 production. IL-2 production did not correlate with clinical activity in patients with RA.
利用12例典型活动期类风湿关节炎患者的滑液（SF）和外周血中的单核细胞，研究了白细胞介素-2（IL-2）的产生调节情况。与12名正常供者的外周血（18.1±15.4单位/毫升）和5例其他风湿性疾病患者的滑液（11.9±10.9单位/毫升）相比，类风湿外周血（5.3±10.9单位/毫升）和滑液（3.8±5.2单位/毫升）中，淋巴细胞受植物血凝素（PHA）刺激产生的IL-2减少。吲哚美辛、佛波酯肉豆蔻酸酯和抑制细胞照射可使类风湿滑液和外周血中的IL-2值升高，但不能恢复正常的IL-2产生。类风湿关节炎患者的IL-2产生与临床活动度无关。
