Altomonte L, Zoli A, Mirone L, Scolieri P, Magaró M
Istituto di Clinica Medica, Universita Cattolica del sacro Cuore, Roma, Italy.
Clin Rheumatol. 1992 Jun;11(2):202-5. doi: 10.1007/BF02207957.
Cytokines are potent immunoregulatory factors and may be directly involved in the disordered immunoregulation found in chronic rheumatic diseases. Interleukin-1b (IL-1b), Interleukin-2 (IL-2) and Tumour Necrosis Factor-a (TNF-a) have been implicated in the pathogenesis of rheumatoid arthritis (RA) as mediators of chronic inflammation. Serum levels of IL-1b and TNF-a measured by radioimmunoassay were significantly higher in patients with RA than in healthy controls of similar sex and age while serum levels of IL-2 were significantly lower in the same patients. Further IL-1b and TNF-a were significantly elevated in RA patients with active disease and IL-2 was significantly reduced when compared with patients with low active disease. Serum IL-1b and TNF-a appear to correlate with systemic inflammation, and systemic features of RA may result from dissemination of cytokines produced in the synovium. The role of IL-2 in RA remains controversial. Reduced levels of IL-2 may be an expression of a deficiency of T-cells to produce IL-2 in the active phases of RA or may be due to a possible absorption of IL-2 by lymphocyte receptors.
细胞因子是强大的免疫调节因子，可能直接参与慢性风湿性疾病中发现的免疫调节紊乱。白细胞介素-1β（IL-1β）、白细胞介素-2（IL-2）和肿瘤坏死因子-α（TNF-α）作为慢性炎症的介质，已被认为与类风湿关节炎（RA）的发病机制有关。通过放射免疫测定法测量，RA患者血清中IL-1β和TNF-α的水平显著高于年龄和性别相似的健康对照组，而同一患者血清中IL-2的水平显著降低。此外，与疾病活动度低的患者相比，疾病活动的RA患者中IL-1β和TNF-α显著升高，而IL-2显著降低。血清IL-1β和TNF-α似乎与全身炎症相关，RA的全身症状可能是由于滑膜中产生的细胞因子扩散所致。IL-2在RA中的作用仍存在争议。IL-2水平降低可能是RA活动期T细胞产生IL-2不足的表现，也可能是由于淋巴细胞受体对IL-2的可能吸收所致。
