Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Off Mlabani Passage, Ifakara, Morogoro, United Republic of Tanzania.
School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Parasit Vectors. 2018 Apr 10;11(1):231. doi: 10.1186/s13071-018-2811-y.
Transfluthrin vapour prevents mosquito bites by disrupting their host-seeking behaviors. We measured the additional benefits of combining transfluthrin-treated sisal decorations and long-lasting insecticidal nets (LLINs) with an aim of extending protection against early evening, indoor-biting malaria vectors when LLINs are ineffective.
We investigated the indoor protective efficacy of locally made sisal decorative baskets (0.28 m) treated with 2.5 ml and 5.0 ml transfluthrin, in terms of mosquito density, exposure to bites and 24 h mortality. Experiments were conducted in experimental huts, located in Lupiro village, Ulanga District, south-eastern Tanzania. Human landing catches (HLC) were used to measure exposure to bites between 19:00-23:00 h. Each morning, at 06:00 h, mosquitoes were collected inside huts and in exit traps and monitored for 24 h mortality.
Sisal decorative baskets (0.28 m) treated with 2.5 ml and 5.0 ml transfluthrin deterred three-quarters of Anopheles arabiensis mosquitoes from entering huts (relative rate, RR = 0.26, 95% confidence interval, CI: 0.20-0.34, P < 0.001 and RR= 0.29, 95% CI: 0.22-0.37, P < 0.001, respectively). Both treatments induced a 10-fold increase in 24 h mortality of An. arabiensis mosquitoes (odds ratio, OR = 12.26, 95% CI: 7.70-19.51, P < 0.001 and OR = 18.42, 95% CI: 11.36-29.90, P < 0.001, respectively).
Sisal decorative items treated with spatial repellents provide additional household and personal protection against indoor biting malaria and nuisance mosquitoes in the early evening, when conventional indoor vector control tools, such as LLINs, are not in use. We recommend future studies to investigate the epidemiological relevance of combining LLINs and transfluthrin decorated baskets in terms of their effect on reduction in malaria prevalence.
四氟苯菊酯蒸气通过扰乱蚊虫的宿主寻找行为来防止蚊虫叮咬。我们测量了将四氟苯菊酯处理的剑麻装饰物和长效驱虫蚊帐（LLIN）相结合的额外益处，目的是在 LLIN 无效时，延长对傍晚室内叮咬疟疾媒介的保护。
我们在坦桑尼亚东南部乌兰加区卢皮罗村的实验棚内，以蚊子密度、叮咬暴露和 24 小时死亡率为指标，调查了用 2.5 毫升和 5.0 毫升四氟苯菊酯处理的本地制造的剑麻装饰篮（0.28 米）的室内保护效果。在 19:00-23:00 时，利用人体诱捕法（HLC）测量叮咬暴露情况。每天早上 06:00，收集棚内和出口陷阱内的蚊子，并监测 24 小时死亡率。
用 2.5 毫升和 5.0 毫升四氟苯菊酯处理的剑麻装饰篮阻止了四分之三的阿拉伯按蚊进入棚内（相对率，RR=0.26，95%置信区间，CI：0.20-0.34，P < 0.001 和 RR=0.29，95%CI：0.22-0.37，P < 0.001）。两种处理方法均使阿拉伯按蚊的 24 小时死亡率增加了 10 倍（比值比，OR=12.26，95%置信区间，CI：7.70-19.51，P < 0.001 和 OR=18.42，95%CI：11.36-29.90，P < 0.001）。
用空间驱避剂处理的剑麻装饰物品为傍晚室内叮咬疟疾和滋扰蚊子提供了额外的家庭和个人保护，此时传统的室内病媒控制工具，如 LLINs，无法使用。我们建议未来的研究调查 LLIN 和四氟苯菊酯装饰篮相结合在降低疟疾发病率方面的流行病学相关性。
