Abouhosseini Tabari Mohaddeseh, Youssefi Mohammad Reza
Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.
Department of Veterinary Parasitology, Babol Branch, Islamic Azad University, Babol, Iran.
Avicenna J Phytomed. 2018 Mar-Apr;8(2):136-142.
Willd. (Geraniaceae) is widely grown as an ornamental plant due to its strong pleasant rose-like odor. The present study evaluates the antitrichomonal effect of essential oil (EO) against both and and compares it to that of metronidazole (MTZ) as a standard antitrichomonal drug.
assays were accomplished in multi-well plates containing MTZ and EO at final concentrations of 2.5, 5, 10, 20, 50, and 100 μg/mL. assay was carried out on 40 experimentally infected pigeons receiving MTZ and EO at doses of 25 and 50 mg/kg.
The 24-hr MIC of MTZ was 10 µg/mL, while for EO it was 20 µg/mL. Treatment with MTZ 50 mg/kg after 4 days led to full recovery of infected pigeons however EO 50 mg/kg resulted in the same outcome after 5 days. No mortality or clinical side effects were seen in treated birds.
The present study introduced EO as a potent natural antitrichomonal agent effective against . Bioactive components of can be used as potential therapeutic compounds in development of novel antitrichomonal drugs.
香叶天竺葵（牻牛儿苗科）因其浓郁宜人的玫瑰香气而被广泛种植作为观赏植物。本研究评估了香叶天竺葵精油（EO）对阴道毛滴虫和人毛滴虫的抗滴虫作用，并将其与标准抗滴虫药物甲硝唑（MTZ）的作用进行比较。
在含有终浓度为2.5、5、10、20、50和100μg/mL的MTZ和EO的多孔板中进行试验。对40只实验感染的鸽子进行试验，分别给予剂量为25和50mg/kg的MTZ和EO。
MTZ的24小时最低抑菌浓度（MIC）为1μg/mL，而EO为2μg/mL。4天后给予50mg/kg的MTZ治疗可使感染鸽子完全康复，然而50mg/kg的EO在5天后产生相同效果。在接受治疗的鸽子中未观察到死亡或临床副作用。
本研究表明EO是一种有效的天然抗滴虫剂，对阴道毛滴虫和人毛滴虫均有效。香叶天竺葵的生物活性成分可作为开发新型抗滴虫药物的潜在治疗化合物。
