Carmen Gâlea, Hancu Gabriel
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University "Lucian Blaga", Sibiu, Romania.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy, Târgu Mureş, Romania.
Adv Pharm Bull. 2014 Dec;4(Suppl 2):511-4. doi: 10.5681/apb.2014.075. Epub 2014 Dec 31.
The antiseptic qualities of aromatic and medicinal plants and their extracts have been recognized since antiquity, while attempts to characterize these properties in the laboratory date back the beginning of the XX(th) century. In the current study essential oils obtained from Pelargonium roseum (Geraniacea) were analyzed for their antibacterial and antifungal activities.
The antimicrobial activity of the Pelargonium essential oil was tested against Gram-negative bacteria (Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli), Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis) and fungi (Candida albicans). Disc diffusion method was used to study antimicrobial activity.
Inhibition zones showed that the studied essential oils were active against all of the studied bacteria. In the case of Candida albicans, the complete inhibition of the fungus's development was observed. In the cases of Pseudomonas aeruginosa and Staphylococcus aureus we observed an inhibition comparable to that obtained by the use of an appropriate antimicrobial substance.
The volatile oils exhibited considerable inhibitory effects against all the organisms under test, in some cases comparable with those of the reference antibiotics. There were no considerable differences between the antimicrobial activities of the oil obtained by distillation and commercially available Pelargonium oils.
芳香植物和药用植物及其提取物的防腐特性自古就已被认可,而在实验室中对这些特性进行表征的尝试可追溯到20世纪初。在本研究中,对从香叶天竺葵(牻牛儿苗科)中提取的精油进行了抗菌和抗真菌活性分析。
测试了香叶天竺葵精油对革兰氏阴性菌(铜绿假单胞菌、奇异变形杆菌、大肠杆菌)、革兰氏阳性菌(金黄色葡萄球菌、粪肠球菌)和真菌(白色念珠菌)的抗菌活性。采用纸片扩散法研究抗菌活性。
抑菌圈表明,所研究的精油对所有研究的细菌均有活性。对于白色念珠菌,观察到真菌的生长完全受到抑制。在铜绿假单胞菌和金黄色葡萄球菌的情况下,我们观察到的抑制作用与使用适当抗菌物质所获得的抑制作用相当。
挥发油对所有受试生物均表现出相当大的抑制作用,在某些情况下与参考抗生素相当。蒸馏获得的精油与市售香叶天竺葵精油的抗菌活性之间没有显著差异。