种子水醇提取物和维生素C对亚临床甲状腺功能亢进大鼠心脏组织生化、血流动力学和功能参数影响的比较。

A comparison of the effects of seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism.

作者信息

Khodadadi Hadi, Pakdel Roghayeh, Khazaei Majid, Niazmand Said, Bavarsad Kowsar, Hadjzadeh Mousa Al-Reza

机构信息

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

The role of authors is equal.

出版信息

Avicenna J Phytomed. 2018 Mar-Apr;8(2):161-169.

OBJECTIVE

The present study was performed to evaluate the effects of hydro-alcoholic extract of () seeds and Vitamin C on biochemical and hemodynamic parameters in cardiac tissue of rats with subclinical hyperthyroidism.

MATERIALS AND METHODS

Forty eight male rats were divided into six groups of 8 and treated for 4 weeks. T4 group received daily injection of levothyroxine sodium (20 μg/kg) and control group was given daily injection of saline. T4-Po groups were given T4 plus 100, 200, and 400 mg/kg of seeds extract in drinking water daily. T4-Vit C group received T4 plus daily injection of Vitamin C (100 mg/kg). At the end of the experiment, body weight, serum free T4 level, left ventricular developed pressure (LVDP), malondialdehyde (MDA) and total thiol levels were measured.

RESULTS

Free T4 levels were increased in all groups that were treated with T4. Weight gain was decreased in T4 and T4-Po100 groups compared to control group (p<0.001 and p<0.05). However, body weight was increased in T4-Po (200 and 400) and T4-Vit C groups compared to T4 group. LVDP was increased in T4 group compared to control group but, LVDP was decreased in T4-Po and T4-Vit C groups. Malondialdehyde was decreased in T4-Po groups and T4-Vit C group compared to T4 group. Total thiol groups were increased in T4-Po (200 and 400) and T4-Vit C groups compared to T4 group.

CONCLUSION

The results showed that extract has a protective effect on cardiac dysfunction due to subclinical hyperthyroidism induced by levothyroxine sodium in rats.

目的

本研究旨在评估（）种子的水醇提取物和维生素C对亚临床甲状腺功能亢进大鼠心脏组织生化和血流动力学参数的影响。

材料与方法

48只雄性大鼠分为6组，每组8只，治疗4周。T4组每日注射左甲状腺素钠（20μg/kg），对照组每日注射生理盐水。T4-Po组每日在饮用水中给予T4加100、200和400mg/kg的种子提取物。T4-Vit C组接受T4加每日注射维生素C（100mg/kg）。实验结束时，测量体重、血清游离T4水平、左心室舒张末压（LVDP）、丙二醛（MDA）和总硫醇水平。

结果

所有接受T4治疗的组中游离T4水平均升高。与对照组相比，T4组和T4-Po100组体重增加减少（p<0.001和p<0.05）。然而，与T4组相比，T4-Po（200和400）组和T4-Vit C组体重增加。与对照组相比，T4组LVDP升高，但T4-Po组和T4-Vit C组LVDP降低。与T4组相比，T4-Po组和T4-Vit C组丙二醛减少。与T4组相比，T4-Po（200和400）组和T4-Vit C组总硫醇增加。