Kaveh Mahsa, Eidi Akram, Nemati Ali, Boskabady Mohammad Hossein
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Biochemistry and Biophysics, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, I.R. Iran.
Avicenna J Phytomed. 2017 Sep-Oct;7(5):409-416.
Previous studies indicated anti-inflammatory effects for in various inflammatory disorders. In this study, the effects of on bronchoalveolar lavage fluid (BALF) levels of total protein (TP), Phospholipase A2 (PLA2) and IgE in sensitized rats were examined.
Male rats were randomly divided into six groups namely, control (group C), sensitized rats (group S), sensitized animal treated with three concentrations of the extract of and dexamethasone (n = 8 for each group). The levels of TP, PLA2 and IgE in BALF were measured.
The levels of TP, PLA2 and IgE were significantly increased in the BALF of group S compared to group C (p<0.001 for all cases). However, treatment of S rats with all concentrations of the extract, resulted in a significant and concentration-dependent reduction in BALF levels of TP, PLA2 and IgE compared to group S (p<0.001 for all cases except for the effect of the low extract concentration on TP). Dexamethasone treatment also led to significant reduction of TP, PLA2 and IgE (p<0.001 for all cases). The effect of dexamethasone treatment on PLA2 was significantly higher than the effects of all extract concentrations (p<0.001 for all cases). However, the effect of high extract concentration on TP and IgE was significantly higher than that of dexamethasone (p<0.001 both cases).
The results indicated anti-inflammatory and immunomodulatory effects of in sensitized rats (as an animal model of asthma) which was equal or more marked than dexamethasone at studied concentrations.
先前的研究表明[提取物名称]对多种炎症性疾病具有抗炎作用。在本研究中，检测了[提取物名称]对致敏大鼠支气管肺泡灌洗液（BALF）中总蛋白（TP）、磷脂酶A2（PLA2）和IgE水平的影响。
雄性大鼠随机分为六组，即对照组（C组）、致敏大鼠组（S组）、用三种浓度的[提取物名称]提取物及地塞米松处理的致敏动物组（每组n = 8）。测量BALF中TP、PLA2和IgE的水平。
与C组相比，S组BALF中TP、PLA2和IgE水平显著升高（所有情况p<0.001）。然而，用所有浓度的提取物处理S组大鼠后，与S组相比，BALF中TP、PLA2和IgE水平显著且呈浓度依赖性降低（除低浓度提取物对TP的影响外，所有情况p<0.001）。地塞米松处理也导致TP、PLA2和IgE显著降低（所有情况p<0.001）。地塞米松处理对PLA2的作用显著高于所有提取物浓度的作用（所有情况p<0.001）。然而，高浓度提取物对TP和IgE的作用显著高于地塞米松（两种情况均p<0.001）。
结果表明[提取物名称]在致敏大鼠（作为哮喘动物模型）中具有抗炎和免疫调节作用，在所研究的浓度下，其作用与地塞米松相当或更显著。
