Daher Mira, El Darazi Elham, Kacim Mohammad, Hobeika Maya, Sacre Yonna
Department of Nutritional Sciences, Faculty of Health Sciences University of Balamand Koura Lebanon.
Department of Nutrition and Food Sciences, Faculty of Arts and Sciences Holy Spirit University of Kaslik Jounieh Lebanon.
Food Sci Nutr. 2025 Jul 24;13(7):e70691. doi: 10.1002/fsn3.70691. eCollection 2025 Jul.
For several decades, non-nutritive sweeteners (NNS) have been used as alternatives to sugar for caloric control, but their metabolic effects remain unclear. In the literature, they were blamed to contribute to several conditions, including obesity. While their effect on body weight has been investigated in numerous studies, the results have been inconsistent. Our study aims to investigate the effect of NNS consumption on body weight, and whether the results vary among different types of sweeteners. A randomized-controlled trial was conducted on a final number of 20 healthy participants over a period of 6 weeks, with an initial screening session and two follow-up sessions. Anthropometric measurements were taken at each visit. While NNS consumers were randomly assigned to the sucralose (0.507 mg/kg; = 7) or stevia group (0.375 mg/kg; = 6), non-consumers were allocated to the control group (no sweeteners; = 7); all were given an isocaloric diet and were counseled to follow a healthy lifestyle. Our results showed that weight and body mass index significantly decreased among controls ( = 0.026; = 0.02) and sucralose ( = 0.028; = 0.017), but not among stevia consumers ( = 0.183; = 0.138). No significant difference was found between groups where no group had a benefit over the other in terms of weight loss. Moreover, no favorable effect of one sweetener was reported over the other. In our population, sucralose and stevia consumption contributed to weight loss that reached significance among sucralose consumers, and could therefore be considered safe for weight management when used as a part of a healthy lifestyle.
几十年来，非营养性甜味剂（NNS）一直被用作糖的替代品以控制热量摄入，但其代谢效应仍不明确。在文献中，它们被指责会导致多种健康问题，包括肥胖。虽然众多研究已对其对体重的影响展开调查，但结果并不一致。我们的研究旨在探究食用NNS对体重的影响，以及不同类型甜味剂的结果是否存在差异。我们对20名健康参与者进行了一项为期6周的随机对照试验，试验包括一次初始筛查和两次随访。每次访视时均进行人体测量。NNS食用者被随机分为三氯蔗糖组（0.507毫克/千克；n = 7）或甜菊糖苷组（0.375毫克/千克；n = 6），非食用者被分配到对照组（不食用甜味剂；n = 7）；所有参与者均给予等热量饮食，并接受健康生活方式指导。我们的结果显示，对照组（P = 0.026；P = 0.02）和三氯蔗糖组（P = 0.028；P = 0.017）的体重和体重指数显著下降，但甜菊糖苷食用者中未出现这种情况（P = 0.183；P = 0.138）。各小组之间未发现显著差异，在体重减轻方面，没有一组比另一组更具优势。此外，未报告一种甜味剂比另一种甜味剂有更有利的效果。在我们的研究人群中，食用三氯蔗糖和甜菊糖苷有助于体重减轻，这在三氯蔗糖食用者中达到显著水平，因此当作为健康生活方式的一部分使用时，可被认为对体重管理是安全的。
