《五味子 A 和 B，两种具有 13 元碳环系统的 5/5/6/11/3 稠合五味子三萜类化合物，来自华中五味子》
Schincalactones A and B, Two 5/5/6/11/3 Fused Schinortriterpenoids with a 13-Membered Carbon Ring System from Schisandra incarnata.
机构信息
School of Pharmacy, Tongji Medical College, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation , Huazhong University of Science and Technology , Wuhan 430030 , P.R. China.
出版信息
Org Lett. 2018 Apr 20;20(8):2499-2502. doi: 10.1021/acs.orglett.8b00889. Epub 2018 Apr 10.
Two novel schinortriterpenoids (SNTs), schincalactones A (1) and B (2), featuring a unique 5/5/6/11/3 ring system, together with schincalide B (3), were isolated from Schisandra incarnata. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configurations of 1 and 3 were confirmed by single-crystal X-ray diffraction. Compounds 1 and 2 possess a 13-membered carbon ring and are the first examples in the SNT family. Plausible biosynthetic pathways of 1-3 were postulated.
从华中五味子中分离得到了两个新型的石杉堿萜（SNTs），即石杉内酯 A（1）和 B（2），它们具有独特的 5/5/6/11/3 环系统，此外还有石杉堿 B（3）。通过详细的光谱分析阐明了它们的结构，并通过单晶 X 射线衍射确定了 1 和 3 的绝对构型。化合物 1 和 2 具有 13 元碳环，是 SNT 家族中的首例。推测了 1-3 的可能生物合成途径。
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