State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China.
Bioorg Chem. 2021 May;110:104785. doi: 10.1016/j.bioorg.2021.104785. Epub 2021 Mar 2.
Schisdilactones K-U (1-11), a series of previously unreported 16,17-secopreschisanartane-type schinortriterpenoids (SNTs), were isolated from the leaves and stems of Schisandra neglecta A. C. Smith. Their structures were mainly established through analysis of their spectroscopic data. Besides, schisdilactones K (1), O (5) and R (8) were confirmed by single-crystal X-ray crystallographic analysis, and the configurations of schisdilactones T and U (10 and 11) were elucidated via quantum chemical calculation of their NMR chemical shifts and electronic circular dichroism (ECD) spectra. Schisdilactones L-S (2-8) and U (11) were found to exhibit moderate protective activities against corticosterone-induced apoptosis of PC12 cells at 20 μM, with cell viability in the range of 62.95-66.97%.
希氏五味子素 K-U（1-11），一组先前未报道的 16,17-裂环preschisanartane 型五味子烷型三萜（SNTs），从希氏五味子 A. C. Smith 的叶和茎中分离得到。它们的结构主要通过分析其光谱数据确定。此外，希氏五味子素 K（1）、O（5）和 R（8）通过单晶 X 射线晶体学分析得到证实，希氏五味子素 T 和 U（10 和 11）的构型通过它们的 NMR 化学位移和电子圆二色谱（ECD）光谱的量子化学计算来阐明。希氏五味子素 L-S（2-8）和 U（11）在 20 μM 时表现出对皮质酮诱导的 PC12 细胞凋亡的中等保护活性，细胞活力在 62.95-66.97%范围内。
